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1. (WO2019002362) CYCLOSPORINE A TOPICAL COMPOSITIONS
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Pub. No.: WO/2019/002362 International Application No.: PCT/EP2018/067237
Publication Date: 03.01.2019 International Filing Date: 27.06.2018
IPC:
A61K 38/13 (2006.01) ,A61K 9/00 (2006.01) ,A61K 47/08 (2006.01) ,A61K 47/10 (2017.01) ,A61K 47/14 (2017.01) ,A61K 47/32 (2006.01) ,A61P 17/06 (2006.01) ,A61K 9/107 (2006.01) ,A61P 17/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12
Cyclic peptides
13
Cyclosporins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
10
Alcohols; Phenols; Salts thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
14
Esters of carboxylic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
32
Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
06
Antipsoriatics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
107
Emulsions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
Applicants:
SPHERIUM BIOMED, S.L. [ES/ES]; Avenida Diagonal, 549, 5p. E-08029 Barcelona, ES
Inventors:
BERGES FRAILE, Maria Isabel; ES
LLUCH LAFUENTE, Nuria; ES
SANTOS LOBO, Benjamín; ES
Agent:
CARBONELL VALLÈS, Enric; ES
Priority Data:
17382404.628.06.2017EP
Title (EN) CYCLOSPORINE A TOPICAL COMPOSITIONS
(FR) COMPOSITIONS TOPIQUES DE CYCLOSPORINE A
Abstract:
(EN) The present invention relates to topical pharmaceutical compositions of cyclosporine A comprising at least a volatile alcohol, 2-(2-ethoxyethoxy)ethanol, a surfactant or surfactant mixture having an HLB value from 10 to 18, and a non-volatile organic solvent other than 2-(2-ethoxyethoxy)ethanol, the surfactants having an HLB value from 10 to 18 and triacetin. The invention also relates to a process for the preparation of said compositions and to their use in the prevention and/or treatment of several diseases, particularly psoriasis and atopic dermatitis.
(FR) La présente invention concerne des compositions pharmaceutiques topiques de cyclosporine A comprenant au moins un alcool volatil, du 2-(2-éthoxyéthoxy)éthanol, un tensioactif ou un mélange tensioactif ayant une valeur HLB de 10 à 18, et un solvant organique non volatil autre que le 2-(2-éthoxyéthoxy)éthanol, les tensioactifs ayant une valeur HLB de 10 à 18 et de la triacétine. L'invention concerne également un procédé de préparation desdites compositions et leur utilisation dans la prévention et/ou le traitement de plusieurs maladies, en particulier le psoriasis et la dermatite atopique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)