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1. (WO2019002324) PARAMETER VALUE ESTIMATION IN COAGULATION SYSTEM
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Pub. No.: WO/2019/002324 International Application No.: PCT/EP2018/067169
Publication Date: 03.01.2019 International Filing Date: 26.06.2018
IPC:
G01N 33/86 (2006.01) ,G01N 33/49 (2006.01) ,G06F 19/12 (2011.01) ,G06F 19/00 (2018.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
86
involving blood coagulating time
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
483
Physical analysis of biological material
487
of liquid biological material
49
blood
G PHYSICS
06
COMPUTING; CALCULATING; COUNTING
F
ELECTRIC DIGITAL DATA PROCESSING
19
Digital computing or data processing equipment or methods, specially adapted for specific applications
10
Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology
12
for modelling or simulation in systems biology, e.g. probabilistic or dynamic models, gene-regulatory networks, protein interaction networks or metabolic networks
G PHYSICS
06
COMPUTING; CALCULATING; COUNTING
F
ELECTRIC DIGITAL DATA PROCESSING
19
Digital computing or data processing equipment or methods, specially adapted for specific applications
Applicants:
KONINKLIJKE PHILIPS N.V. [NL/NL]; High Tech Campus 5 5656 AE Eindhoven, NL
Inventors:
BAKKER, Bart, Jacob; NL
VAN OOIJEN, Hendrik, Jan; NL
VAN DEN HAM, René; NL
Agent:
DE HAAN, Poul, Erik; NL
Priority Data:
17178329.328.06.2017EP
Title (EN) PARAMETER VALUE ESTIMATION IN COAGULATION SYSTEM
(FR) ESTIMATION DE VALEUR DE PARAMÈTRE DANS UN SYSTÈME DE COAGULATION
Abstract:
(EN) The present invention relates to a method for estimating a value of a parameter of a blood coagulation system in a subject that is periodically supplied with an anticoagulant, wherein the parameter of the coagulation system is a time taken for the coagulation system to reach a state of coagulation after periodic supply of anticoagulant to the subject is discontinued. The value of the parameter of the coagulation system is estimated based on concentration levels of 5 or 6 coagulation proteins derived from the coagulation system at a predetermined point in time relative to a point in time of supply of a last dose of anticoagulant to the coagulation system. In one embodiment the 5 coagulation proteins are coagulation factor VII (F7), coagulation factor IX (F9), Anti-thrombin (AT), coagulation factor X (F10), and coagulation factor VIII (F8). Optionally the 6th coagulation protein is coagulation factor XI (F11).
(FR) La présente invention concerne un procédé d’estimation d’une valeur d’un paramètre d’un système de coagulation sanguine chez un sujet qui est périodiquement approvisionné en anticoagulant, le paramètre du système de coagulation étant un temps nécessaire pour que le système de coagulation atteigne un état de coagulation après que la distribution périodique d’anticoagulant au sujet est interrompue. La valeur du paramètre du système de coagulation est estimée sur la base de niveaux de concentration de 5 ou 6 protéines de coagulation dérivées du système de coagulation à un temps prédéterminé par rapport à un temps de distribution d’une dernière dose d’anticoagulant au système de coagulation. Dans un mode de réalisation, les 5 protéines de coagulation sont le facteur de coagulation VII (F7), le facteur de coagulation IX (F9), l’antithrombine (AT), le facteur de coagulation X (F10) et le facteur de coagulation VIII (F8). Facultativement, la 6ème protéine de coagulation est le facteur de coagulation XI (F11).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)