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1. (WO2019001419) NEW QUINOLINONE COMPOUNDS
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Pub. No.: WO/2019/001419 International Application No.: PCT/CN2018/092830
Publication Date: 03.01.2019 International Filing Date: 26.06.2018
IPC:
C07D 403/02 (2006.01) ,C07D 403/14 (2006.01) ,A61K 31/435 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
JANSSEN PHARMACEUTICA NV [BE/BE]; Turnhoutseweg 30, Beerse 2340, BE
JOHNSON & JOHNSON (CHINA) INVESTMENT LTD. [CN/CN]; 2101, No.1 Building, 65 Gui Qing Road, Xuhui District Shanghai 200233, CN (SC)
Inventors:
GUO, Haibing; CN
WAN, Zhao-Kui; US
QIN, Luoheng; CN
LIU, Qian; CN
CHEUNG, Wing Shun; CN
Agent:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD.; 10th Floor, Tower C, Beijing Global Trade Center, 36 North Third Ring Road East, Dongcheng District Beijing 100013, CN
Priority Data:
PCT/CN2017/09026727.06.2017CN
Title (EN) NEW QUINOLINONE COMPOUNDS
(FR) NOUVEAUX COMPOSÉS DE QUINOLÉINONE
Abstract:
(EN) Provided are new quinolinone compounds, pharmaceutical compositions comprising said compounds, processes for the preparation of said compounds and the use of said compounds as FGFR inhibitors and their use in the treatment of diseases, e.g. cancer.
(FR) L'invention concerne de nouveaux composés de quinoléinone, des compositions pharmaceutiques comprenant lesdits composés, des procédés de préparation desdits composés et l'utilisation desdits composés en tant qu'inhibiteurs de FGFR et leur utilisation dans le traitement de maladies, par exemple le cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)