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1. (WO2019001325) CRYSTAL FORM XV OF LESINURAD AND PREPARATION METHOD THEREFOR
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Pub. No.: WO/2019/001325 International Application No.: PCT/CN2018/092075
Publication Date: 03.01.2019 International Filing Date: 21.06.2018
IPC:
C07D 249/12 (2006.01) ,A61K 31/4196 (2006.01) ,A61P 19/06 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
249
Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
02
not condensed with other rings
08
1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
10
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
12
Oxygen or sulfur atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4196
1,2,4-Triazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
06
Antigout agents, e.g. antihyperuricemic or uricosuric agents
Applicants:
苏州科睿思制药有限公司 CRYSTAL PHARMACEUTICAL (SUZHOU) CO., LTD. [CN/CN]; 中国江苏省苏州市工业园区星湖街218号生物纳米园B4-301赵林林 ZHAO, Linlin B4-301, Biobay, 218 Xinghu Street, Suzhou Industrial Park Suzhou, Jiangsu 215123, CN
Inventors:
陈敏华 CHEN, Minhua; CN
张炎锋 ZHANG, Yanfeng; CN
王金秋 WANG, Jinqiu; CN
黄春香 HUANG, Chunxiang; CN
张晓宇 ZHANG, Xiaoyu; CN
杨朝惠 YANG, Chaohui; CN
Priority Data:
201710507676.328.06.2017CN
Title (EN) CRYSTAL FORM XV OF LESINURAD AND PREPARATION METHOD THEREFOR
(FR) FORME CRISTALLINE XV DE LÉSINURAD ET SON PROCÉDÉ DE PRÉPARATION
(ZH) 雷西纳得的晶型XV及其制备方法
Abstract:
(EN) The present invention relates to a new crystal form of lesinurad, a preparation method therefor, a pharmaceutical composition containing the crystal form, and use of the crystal form in the preparation of a uric acid transporter inhibitor and a pharmaceutical preparation for treating hyperuricemia. The new crystal form of lesinurad provided in the present invention has one or more improved properties with respect to those in the prior art, having great value in the optimization and development of this medicament in the future.
(FR) La présente invention concerne une nouvelle forme cristalline de lésinurad, un procédé de préparation correspondant, une composition pharmaceutique contenant la forme cristalline et l'utilisation de cette forme cristalline dans la préparation d'un inhibiteur du transporteur de l'acide urique, ainsi qu'une préparation pharmaceutique destinée au traitement de l'hyperuricémie. La nouvelle forme cristalline de lésinurad de la présente invention possède au moins une propriété améliorée par rapport à celles de l'état de la technique, possédant une grande valeur dans l'optimisation et la mise au point de ce médicament à l'avenir.
(ZH) 本发明涉及一种雷西纳得的新晶型及其制备方法,含有该晶型的药物组合物,以及该晶型在制备尿酸转运蛋白抑制剂和治疗高尿酸血症药物制剂中的用途。本发明提供的雷西纳得新晶型与现有技术相比具有一种或多种改进的特性,对未来该药物的优化和开发具有重要价值。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)