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1. (WO2019001307) AMIDE COMPOUND, COMPOSITION CONTAINING SAME, AND USE THEREOF
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Pub. No.: WO/2019/001307 International Application No.: PCT/CN2018/091829
Publication Date: 03.01.2019 International Filing Date: 19.06.2018
IPC:
C07D 417/12 (2006.01) ,C07D 209/34 (2006.01) ,A61K 31/4035 (2006.01) ,A61K 31/427 (2006.01) ,A61P 35/00 (2006.01) ,A61P 37/00 (2006.01) ,A61P 9/00 (2006.01) ,A61P 31/12 (2006.01) ,A61P 3/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
04
Indoles; Hydrogenated indoles
30
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
32
Oxygen atoms
34
in position 2
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403
condensed with carbocyclic rings, e.g. carbazole
4035
Isoindoles, e.g. phthalimide
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
427
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
Applicants:
深圳市塔吉瑞生物医药有限公司 SHENZHEN TARGETRX, INC. [CN/CN]; 中国广东省深圳市 南山区科苑路15号科兴科学园A1栋301 Room 301, Building A1, Kexing Science Park, No.15 Of Keyuan Road Nanshan District, Shenzhen, Guangdong 518057, CN
Inventors:
王义汉 WANG, Yihan; CN
赵九洋 ZHAO, Jiuyang; CN
Priority Data:
201710492901.026.06.2017CN
Title (EN) AMIDE COMPOUND, COMPOSITION CONTAINING SAME, AND USE THEREOF
(FR) COMPOSÉ AMIDE, COMPOSITION LE CONTENANT, ET UTILISATION ASSOCIÉE
(ZH) 一种酰胺类化合物及包含该化合物的组合物及其用途
Abstract:
(EN) An amide compound of formula (I), a polymorph, a pharmaceutically acceptable salt, a prodrug, a stereoisomer, an isotope variant, a hydrate, or a solvate thereof, a pharmaceutical composition containing the compound, and a pharmaceutical use thereof. The compound and the pharmaceutical composition have excellent protein kinase inhibitory activity and good pharmacokinetic properties, can increase drug concentrations of the compound in animals, and improve the efficacy and safety of the drug.
(FR) L'invention concerne un composé amide de formule (I), un polymorphe, un sel pharmaceutiquement acceptable, un promédicament, un stéréoisomère, un variant isotope, un hydrate ou un solvate de celui-ci, une composition pharmaceutique le contenant, et une utilisation pharmaceutique de celui-ci. Le composé et la composition pharmaceutique, selon l'invention possèdent une excellente activité inhibitrice de protéine kinase et présentent de bonnes propriétés pharmacocinétiques, peuvent augmenter les concentrations médicamenteuses du composé chez des animaux, et peuvent améliorer l'efficacité et la sécurité du médicament.
(ZH) 一种式(I)所示的酰胺类化合物,其多晶型、药学上可接受的盐、前药、立体异构体、同位素变体、水合物或溶剂合物,包含该化合物的药物组合物及其制药用途,所述化合物及药物组合物具有优异的蛋白激酶抑制活性和良好的药代动力学性能,能够提高化合物在动物体内的药物浓度,提高药物疗效和安全性。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)