Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2019001292) PREPARATION METHOD OF NEW COMPOUND OF 4'-THIONUCLEOSIDE AND INTERMEDIATE IN THE PREPARATION METHOD
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/001292 International Application No.: PCT/CN2018/091514
Publication Date: 03.01.2019 International Filing Date: 15.06.2018
IPC:
C07H 19/06 (2006.01) ,C07H 19/16 (2006.01) ,C07H 19/10 (2006.01) ,C07H 19/20 (2006.01) ,C07H 1/00 (2006.01) ,C07F 7/18 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
06
Pyrimidine radicals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
16
Purine radicals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
06
Pyrimidine radicals
10
with the saccharide radical being esterified by phosphoric or polyphosphoric acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
16
Purine radicals
20
with the saccharide radical being esterified by phosphoric or polyphosphoric acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1
Processes for the preparation of sugar derivatives
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
7
Compounds containing elements of the 4th Group of the Periodic System
02
Silicon compounds
08
Compounds having one or more C-Si linkages
18
Compounds having one or more C-Si linkages as well as one or more C-O-Si linkages
Applicants:
四川科伦博泰生物医药股份有限公司 SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. [CN/CN]; 中国四川省成都市 温江区海峡两岸科技产业开发园区新华大道二段666号 No.666, Xinhua Avenue (Section 2), Hai Xia Industrial Park, Wenjiang District Chengdu, Sichuan 611138, CN
Inventors:
周江峰 ZHOU, Jiangfeng; CN
梁玉峰 LIANG, Yufeng; CN
王强 WANG, Qiang; CN
王涛 WANG, Tao; CN
韩维彪 HAN, Weibiao; CN
李友强 LI, Youqiang; CN
魏海东 WEI, Haidong; CN
葛建华 GE, Jianhua; CN
赵忠琼 ZHAO, Zhongqiong; CN
文乾映 WEN, Qianying; CN
吴灵静 WU, Lingjing; CN
田强 TIAN, Qiang; CN
赵明亮 ZHAO, Mingliang; CN
曾宏 ZENG, Hong; CN
蔡家强 CAI, Jiaqiang; CN
王利春 WANG, Lichun; CN
王晶翼 WANG, Jingyi; CN
Agent:
北京永新同创知识产权代理有限公司 NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD; 中国北京市 东城区北三环东路36号北京环球贸易中心C座10层 10th Floor, Tower C, Beijing Global Trade Center, 36 North Third Ring Road East, Dongcheng District Beijing 100013, CN
Priority Data:
201710513557.929.06.2017CN
Title (EN) PREPARATION METHOD OF NEW COMPOUND OF 4'-THIONUCLEOSIDE AND INTERMEDIATE IN THE PREPARATION METHOD
(FR) PROCÉDÉ DE PRÉPARATION D’UN NOUVEAU COMPOSÉ DE 4’-THIONUCLÉOSIDE ET INTERMÉDIAIRE DANS LE PROCÉDÉ DE PRÉPARATION
(ZH) 4'-硫代核苷的新型化合物的制备方法和此制备方法中的中间体
Abstract:
(EN) A method for preparing a compound of formula T-3 according to route I is disclosed. The method comprises the following steps: a first step of reacting a compound of formula T-1 with a reagent comprising a PG group in the presence of an organic base or an inorganic base, optionally under the catalysis of a catalyst, to form a compound of formula T-2; and a second step of reacting the compound of formula T-2 under the catalysis of an organic base or an inorganic base to form the compound of formula T-3. A method for preparing a compound of formula (I)-1 according to route II is further disclosed. The method comprises the following steps: step A, reacting T-3 with R-1 in the presence of a hydroxyl hydrogen removal reagent to obtain a compound of formula T-4; and step B, reacting the compound of formula T-4 under the catalysis of an organic base or an inorganic base, or in the presence of a fluorine-containing reagent, to obtain the compound of formula (I)-1. In addition, an intermediate in the above preparation methods is further disclosed.
(FR) La présente invention concerne un procédé de préparation d’un composé de formule T-3 selon la voie (I). Le procédé comprend les étapes suivantes : une première étape de réaction d’un composé de formule T-1 avec un réactif comprenant un groupe PG en présence d’une base organique ou d’une base inorganique, éventuellement sous la catalyse d’un catalyseur, pour former un composé de formule T-2 ; et une seconde étape de réaction du composé de formule T-2 sous la catalyse d’une base organique ou d’une base inorganique pour former le composé de formule T-3. La présente invention concerne également un procédé de préparation d’un composé de formule (I)-1 selon la voie (II). Le procédé comprend les étapes suivantes : étape A, réaction de T-3 avec R-1 en présence d’un réactif d’élimination de l'hydrogène d’un groupe hydroxyle pour obtenir un composé de formule T-4 ; et étape B, réaction du composé de formule T-4 sous la catalyse d’une base organique ou d’une base inorganique, ou en présence d’un réactif contenant du fluor, pour obtenir le composé de formule (I)-1. De plus, l’invention concerne également un intermédiaire dans les procédés de préparation ci-dessus.
(ZH) 公开了按照路线I制备式T-3的化合物的方法,所述方法包括以下步骤:第一步,将式T-1的化合物与包含PG基团的试剂在有机碱或无机碱存在下,任选地在催化剂的催化下反应,生成式T-2的化合物;以及第二步,将式T-2的化合物在有机酸或无机酸的催化下反应,生成式T-3的化合物。还公开了按照路线II制备式(I)-1的化合物的方法,所述方法包括以下步骤:步骤A,使T-3和R-1在羟基氢移除试剂的存在下反应,得到式T-4的化合物;以及步骤B,将式T-4的化合物在有机酸或无机酸的催化下,或者在含氟试剂的存在下反应,得到式(I)-1的化合物。另外,还公开了上述制备方法中的中间体。
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)