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1. (WO2019001171) PHOSPHORUS-CONTAINING COMPOUND AND PREPARATION AND USE THEREOF
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Pub. No.: WO/2019/001171 International Application No.: PCT/CN2018/087629
Publication Date: 03.01.2019 International Filing Date: 21.05.2018
IPC:
C07F 9/32 (2006.01) ,C07F 9/50 (2006.01) ,C07F 9/30 (2006.01) ,C07F 9/28 (2006.01) ,A61K 31/662 (2006.01) ,A61K 31/66 (2006.01) ,A61P 27/02 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
28
with one or more P-C bonds
30
Phosphinic acids (R2P(:O)OH); Thiophosphinic acids
32
Esters thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
28
with one or more P-C bonds
50
Organo-phosphines
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
28
with one or more P-C bonds
30
Phosphinic acids (R2P(:O)OH); Thiophosphinic acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
28
with one or more P-C bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
662
Phosphorus acids or esters thereof having P-C bonds, e.g. foscarnet, trichlorfon
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27
Drugs for disorders of the senses
02
Ophthalmic agents
Applicants:
维眸生物科技上海有限公司 VIVAVISIONSHANGHAILTD [CN/CN]; 中国上海市 中国(上海)自由贸易试验区爱迪生路334号5幢207、209室 Room 207, 209 Building 5 No. 334 Aidisheng Rd, Zhangjiang High Tech Park, Pudong District Shanghai 201203, CN
Inventors:
沈旺 SHEN, Wang; CN
丁悦 DING, Yue; CN
姜浩 JIANG, Hao; CN
陈福利 CHEN, Fu li; CN
汪江峰( WANG, Jiangfeng; CN
吴兴龙 WU, Xinglong; CN
李寸飞 LI, Cunfei; CN
杨立国 YANG, Liguo; CN
胡彪 HU, Biao; CN
姜启阳 JIANG, Qiyang; CN
安治星 AN, Zhixing; CN
党奎峰 DANG, Kuifeng; CN
Agent:
上海精晟知识产权代理有限公司 SHANGHAI CPTO INTELLECTUAL PROPERTY AGENCY CO. LTD; 中国上海市 杨浦区控江路1555号A座1105室 Room 1105 Building A No.1555 Kong Jiang Road, Yangpu District Shanghai 200092, CN
杜 DU; 中国上海市 杨浦区控江路1555号A座2705室 Room 1105 Building A No.1555 Kong Jiang Road,Yangpu District Shanghai 200092, CN
Priority Data:
201710502653.327.06.2017CN
201810291023.003.04.2018CN
Title (EN) PHOSPHORUS-CONTAINING COMPOUND AND PREPARATION AND USE THEREOF
(FR) COMPOSÉ CONTENANT DU PHOSPHORE, PRÉPARATION ET UTILISATION ASSOCIÉES
(ZH) 一种含磷化合物及其制备和应用
Abstract:
(EN) Provided is a phosphorus-containing compound characterized by being a compound represented by the following structure: the compound is a novel immunocyte migration inhibitor. The compound has good hydrophilicity and can be developed into eye drops. The compound has a strong inhibitory ability to immunocyte migration and can relieve the symptoms of most dry-eye patients.
(FR) L'invention concerne un composé contenant du phosphore caractérisé en ce qu'il est représenté par la structure suivante : le composé est un nouvel inhibiteur de migration d'immunocytes. Le composé présente un bon caractère hydrophile et peut être développé en gouttes oculaires. Le composé selon l'invention possède une forte capacité inhibitrice vis-à-vis de la migration des immunocytes et peut soulager les symptômes de la plupart des patients à sécheresse oculaire.
(ZH) 本发明提供了一种含磷化合物,其特征在于,为如下结构所示的化合物:该化合物为新型的免疫细胞迁徙抑制剂。有很好的亲水性,可以开发成眼药水。对免疫细胞迁徙有很强的抑制能力,可以缓解大多数干眼症病人的症状。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)