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1. (WO2019000605) METHOD FOR INHIBITING MYOPIA AND APPLICATION IN PREPARING DRUG
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Pub. No.: WO/2019/000605 International Application No.: PCT/CN2017/097575
Publication Date: 03.01.2019 International Filing Date: 16.08.2017
Chapter 2 Demand Filed: 13.06.2018
IPC:
A61K 45/00 (2006.01) ,A61K 31/7034 (2006.01) ,A61K 31/352 (2006.01) ,A61P 27/10 (2006.01) ,A61P 27/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7028
Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7034
attached to a carbocyclic compound, e.g. phloridzin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
35
having six-membered rings with one oxygen as the only ring hetero atom
352
condensed with carbocyclic rings, e.g. cannabinols, methantheline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27
Drugs for disorders of the senses
02
Ophthalmic agents
10
for accommodation disorders, e.g. myopia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27
Drugs for disorders of the senses
02
Ophthalmic agents
Applicants:
温州医科大学 WENZHOU MEDICAL UNIVERSITY [CN/CN]; 中国浙江省温州市 瓯海经济开发区东方南路38号006信箱 PO Box 006, No.38 South Dongfang Road, Ouhai Economic Development Zone Wenzhou, Zhejiang 325000, CN
Inventors:
周翔天 ZHOU, Xiangtian; CN
瞿佳 QU, Jia; CN
赵斐 ZHAO, Fei; CN
潘妙珍 PAN, Miaozhen; CN
张森 ZHANG, Sen; CN
周清怡 ZHOU, Qingyi; CN
吴昊 WU, Hao; CN
Agent:
温州金瓯专利事务所(普通合伙) WENZHOU JINOU PATENT LAW OFFICE (GENERAL PARTNERSHIP); 中国浙江省温州市 高新技术产业开发区创业服务中心科技企业孵化器C幢309、311室 Rm 309 & 311, Bldg C, Business Incubation Center, High-tech Industrial Development Zone Wenzhou, Zhejiang 325000, CN
Priority Data:
201710511445.X29.06.2017CN
Title (EN) METHOD FOR INHIBITING MYOPIA AND APPLICATION IN PREPARING DRUG
(FR) MÉTHODE D'INHIBITION DE LA MYOPIE ET APPLICATION DANS LA PRÉPARATION D'UN MÉDICAMENT
(ZH) 一种抑制近视的方法及制备药物的应用
Abstract:
(EN) The present invention relates to a method for inhibiting myopia and an application in preparing a drug. By inhibiting HIF-1α expression in eyes, anti-hypoxic effect is achieved, thereby inhibiting myopia. By inhibiting the functions of HIF-1α in eyes, anti-hypoxic effect is achieved, and thus myopia can be effectively delayed or inhibited. The present invention uses HIF-1α inhibitors, salidroside and formononetin, to inhibit HIF-1α activity, thereby achieving anti-hypoxic effect, and thus myopia can be significantly delayed.
(FR) La présente invention concerne une méthode d'inhibition de la myopie et une application dans la préparation d'un médicament. En inhibant l'expression de HIF-1α dans les yeux, un effet anti-hypoxique est obtenu, ce qui permet d'inhiber la myopie. En inhibant les fonctions de HIF-1α dans les yeux, un effet anti-hypoxique est obtenu, et ainsi la myopie peut être efficacement retardée ou inhibée. La présente invention utilise des inhibiteurs de HIF-1α, le salidroside et la formononétine, pour inhiber l'activité de HIF-1α, ce qui permet d'obtenir un effet anti-hypoxique, et ainsi la myopie peut être significativement retardée.
(ZH) 本发明涉及一种抑制近视的方法及制备药物的应用,通过抑制眼内HIF-1α的表达起到抗缺氧作用而抑制近视,通过抑制眼内HIF-1α的作用起到抗缺氧的作用,可以有效地延缓、抑制近视,本发明利用HIF-1α抑制剂红景天苷和芒柄花黄素抑制HIF-1α活性起到抗缺氧作用,可明显起到延缓近视的作用。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)