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1. (WO2019000327) METHOD FOR ADMINISTERING TRAIL PROTEIN SO AS TO CONTINUOUSLY INHIBIT TUMOR CELL GROWTH
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Pub. No.: WO/2019/000327 International Application No.: PCT/CN2017/090826
Publication Date: 03.01.2019 International Filing Date: 29.06.2017
IPC:
A61K 39/395 (2006.01) ,A61P 35/00 (2006.01) ,C07K 16/28 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
Applicants:
成都华创生物技术有限公司 CHENGDU HUACHUANG BIOTECHNOLOGY CO., LTD [CN/CN]; 中国四川省成都市 高新区科高新区科园南路88号12栋4层409号 Room 409, Floor 4, Building 12 No. 88, South Keyuan Road, Gaoxin District Chengdu, Sichuan 610000, CN
Inventors:
陈守春 CHEN, Shouchun; CN
闫娟 YAN, Juan; CN
徐琦 XU, Qi; CN
胡海洋 HU, Haiyang; CN
黄先洲 HUANG, Xianzhou; CN
魏利佳 WEI, Lijia; CN
Agent:
北京联瑞联丰知识产权代理事务所(普通合伙) BEIJING UTC LIANFENG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP); 中国广东省广州市 经济开发区科学大道231-233号A9-A10栋1-4楼 Floor 1-4, Building A9-A10 No. 231-233, Science Avenue Economic & Technological Development District Guangzhou, Guangdong 510000, CN
Priority Data:
Title (EN) METHOD FOR ADMINISTERING TRAIL PROTEIN SO AS TO CONTINUOUSLY INHIBIT TUMOR CELL GROWTH
(FR) PROCÉDÉ D'ADMINISTRATION DE PROTÉINE TRAIL DE FAÇON À INHIBER EN CONTINU LA CROISSANCE DE CELLULES TUMORALES
(ZH) 一种TRAIL类蛋白持续抑制肿瘤细胞生长的给药方法
Abstract:
(EN) Provided is a method for administering a tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) protein so as to continuously inhibit tumor cell growth, the specific method comprising administration by means of intermittent, repeated and full-course treatment drug exposure; by means of prolonging an administration interval and increasing drug exposure time for tumor cells during full-course treatment, the action of the drug during full-course treatment does not attenuate, thereby continuously inhibiting tumor growth.
(FR) L'invention concerne un procédé d'administration d'une protéine TRAIL (ligand inducteur d'apoptose lié au facteur de nécrose tumorale (TNF)) de manière à inhiber en continu la croissance de cellules tumorales, le procédé spécifique comprenant l'administration au moyen d'une exposition à un médicament de traitement intermittente, répétée et complète ; par le biais de la prolongation d'un intervalle d'administration et de l'augmentation du temps d'exposition au médicament pour des cellules tumorales pendant un traitement complet, l'action du médicament pendant un traitement complet n'est pas atténuée, ce qui permet d'inhiber en continu la croissance tumorale.
(ZH) 提供了一种TRAIL类蛋白持续抑制肿瘤细胞生长的给药方法,具体方法是间隔、重复及全疗程药物暴露的给药,通过延长给药间隔,增加肿瘤细胞在全疗程的药物暴露时间,使药物在全疗程的作用不衰减,从而持续抑制肿瘤生长。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)