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1. (WO2018228907) DIAZABICYCLIC SUBSTITUTED IMIDAZOPYRIMIDINES AND THEIR USE FOR THE TREATMENT OF BREATHING DISORDERS
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Pub. No.: WO/2018/228907 International Application No.: PCT/EP2018/064977
Publication Date: 20.12.2018 International Filing Date: 07.06.2018
IPC:
C07D 471/08 (2006.01) ,C07D 498/08 (2006.01) ,A61K 31/4995 (2006.01) ,A61K 31/5386 (2006.01) ,A61P 11/00 (2006.01) ,A61P 25/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
08
Bridged systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
498
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
08
Bridged systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4995
Pyrazines or piperazines forming part of bridged ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
535
having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5375
1,4-Oxazines, e.g. morpholine
5386
spiro-condensed or forming part of bridged ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
Applicants:
BAYER AKTIENGESELLSCHAFT [DE/DE]; Kaiser-Wilhelm-Allee 1 51373 Leverkusen, DE
BAYER PHARMA AKTIENGESELLSCHAFT [DE/DE]; Müllerstr. 178 13353 Berlin, DE
Inventors:
DELBECK, Martina; DE
HAHN, Michael; DE
MÜLLER, Thomas; DE
LUSTIG, Klemens; DE
COLLINS, Karl; DE
LINDNER, Niels; DE
NICOLAI, Janine; DE
BECK-BROICHSITTER, Moritz; DE
ALBUS, Udo; DE
GEHRING, Doris; DE
ROSENSTEIN, Björn; DE
Agent:
BIP PATENTS; Alfred-Nobel-Str. 10 40789 Monheim am Rhein NRW, DE
Priority Data:
17176046.514.06.2017EP
17193252.826.09.2017EP
Title (EN) DIAZABICYCLIC SUBSTITUTED IMIDAZOPYRIMIDINES AND THEIR USE FOR THE TREATMENT OF BREATHING DISORDERS
(FR) IMIDAZOPYRIMIDINES À SUBSTITUTION DIAZABICYCLIQUE ET LEUR UTILISATION POUR TRAITER DES MALADIES DES VOIES RESPIRATOIRES
(DE) DIAZABICYCLISCH SUBSTITUIERTE IMIDAZOPYRIMIDINE UND IHRE VERWENDUNG ZUR BEHANDLUNG VON ATEMSTÖRUNGEN
Abstract:
(EN) The present invention relates to novel diazabicyclic substituted imidazo[l,2-a]pyrimidine- derivatives, to methods for producing the same, to the use thereof either alone or in combination for the treatment and/or prevention of diseases, as well as to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnea and snoring.
(FR) La présente invention concerne de nouveaux dérivés d'imidazol[1,2-a]pyrimidine à substitution diazabicyclique, des procédés permettant de fabriquer lesdits dérivés, leur utilisation individuellement ou en combinaisons pour le traitement et/ou la prévention de maladies, ainsi que leur utilisation pour la fabrication de médicaments destinés au traitement et/ou à la prévention de maladies, en particulier destinés au traitement et/ou à la prévention de maladies des voies respiratoires, y compris de maladies des voies respiratoires liées au sommeil, telles que l’apnée obstructive et l'apnée centrale du sommeil ainsi que la ronchopathie.
(DE) Die vorliegende Anmeldung betrifft neue, diazabicyclisch substituierte Imidazo[l,2-a]pyrimidin- Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung allein oder in Kombinationen zur Behandlung und/oder Prävention von Krankheiten sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prävention von Krankheiten, insbesondere zur Behandlung und/oder Prävention von Atemstörungen, einschließlich schlafbedingter Atemstörungen wie obstruktiven und zentralen Schlafapnoen und Schnarchen.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: German (DE)
Filing Language: German (DE)