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1. (WO2018228081) METHOD FOR SYNTHESIZING 4-HYDROXYBENZOIC ACID BY USING P-XYLENE (PX) AS RAW MATERIAL
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Pub. No.: WO/2018/228081 International Application No.: PCT/CN2018/085754
Publication Date: 20.12.2018 International Filing Date: 05.05.2018
IPC:
C07C 51/265 (2006.01) ,C07C 51/285 (2006.01) ,C07C 51/275 (2006.01) ,C07C 51/305 (2006.01) ,C07C 65/01 (2006.01) ,B01J 31/22 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
51
Preparation of carboxylic acids or their salts, halides, or anhydrides
16
by oxidation
21
with molecular oxygen
255
of compounds containing six-membered aromatic rings without ring-splitting
265
having alkyl side chains which are oxidised to carboxyl groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
51
Preparation of carboxylic acids or their salts, halides, or anhydrides
16
by oxidation
285
with peroxy-compounds
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
51
Preparation of carboxylic acids or their salts, halides, or anhydrides
16
by oxidation
27
with oxides of nitrogen or nitrogen-containing mineral acids
275
of hydrocarbyl groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
51
Preparation of carboxylic acids or their salts, halides, or anhydrides
16
by oxidation
305
with sulfur or sulfur-containing compounds
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
65
Compounds having carboxyl groups bound to carbon atoms of six-membered aromatic rings and containing any of the groups OH, O-metal, -CHO, keto, ether, groups, groups, or groups
01
containing hydroxy or O-metal groups
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
J
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS, COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
31
Catalysts comprising hydrides, coordination complexes or organic compounds
16
containing coordination complexes
22
Organic complexes
Applicants:
云南大学 YUNNAN UNIVERSITY [CN/CN]; 中国云南省昆明市 五华区翠湖北路2号王家强 WANG, Jiaqiang No.2, Lake North Road, Wuhua District Kunming, Yunnan 650091, CN
Inventors:
王家强 WANG, Jiaqiang; CN
李应 LI, Ying; CN
陈道梅 CHENG, Daomei; CN
Agent:
昆明今威专利商标代理有限公司 KUNMING JINWEI PATENT & TRADEMARK AGENT LTD.; 中国云南省昆明市 盘龙区北京路542号省科技大楼15层赛晓刚 SAI, Xiaogan 15/F, Science-Technology Bldg, No. 542 Beijing Rd. Kunming, Yunnan 650051, CN
Priority Data:
201710451197.415.06.2017CN
Title (EN) METHOD FOR SYNTHESIZING 4-HYDROXYBENZOIC ACID BY USING P-XYLENE (PX) AS RAW MATERIAL
(FR) PROCÉDÉ DE SYNTHÈSE D'ACIDE 4-HYDROXYBENZOÏQUE EN UTILISANT DU P-XYLÈNE (PX) COMME MATIÈRE PREMIÈRE
(ZH) 一种以对二甲苯(PX)为原料合成对羟甲基苯甲酸的方法
Abstract:
(EN) Discloses is a method for synthesizing 4-hydroxybenzoic acid by using PX as a raw material. PX is dissolved in an organic solvent and undergoes oxidation reaction with an oxidant under the action of an M-MOF catalyst, after the reaction is completed, post-treatment is performed to obtain 4-hydroxybenzoic acid. The metal element M in the M-MOF catalyst is Fe, Cu, Cr, Mn, Cu/Fe, Cu/Cr, Cu/Mn, Fe/Mn, Cr/Fe or Cr/Mn. The raw materials of the present invention are abundant in sources and low in price; less by-products are generated in the reaction process, the yield is high, and separation is convenient; acid-base neutralization is not needed in the reaction process, and pollution is reduced; and the present invention is a one-step reaction and is mild in reaction conditions, short in reaction time, low in pollution, and convenient for industrialized scale-up production. The prepared 4-hydroxybenzoic acid can be used for preparing medicines, liquid crystal materials, etc., is widely used and has high value.
(FR) L'invention concerne un procédé de synthèse d'acide 4-hydroxybenzoïque en utilisant le PX en tant que matière première. Le PX est dissous dans un solvant organique et subit une réaction d'oxydation avec un oxydant sous l'action d'un catalyseur M-MOF, après que la réaction a été achevée, un post-traitement est effectué pour obtenir l'acide 4-hydroxybenzoïque. L'élément métallique M dans le catalyseur M-MOF est le Fe, Cu, Cr, Mn, Cu/Fe, Cu/Cr, Cu/Mn, Fe/Mn, Cr/Fe ou Cr/Mn. Les matières premières de la présente invention sont de sources abondantes et peu coûteuses ; moins de sous-produits sont générés dans le processus de réaction, le rendement est élevé, et la séparation est pratique ; la neutralisation acide-base n'est pas nécessaire dans le processus de réaction, et la pollution est réduite ; et la présente invention est une réaction en une étape ayant des conditions de réaction modérées et une durée de réaction est courte, faiblement polluante et pratique pour la production à l'échelle industrialisée. L'acide 4-hydroxybenzoïque préparé peut être utilisé pour préparer des médicaments, des matériaux à cristaux liquides, etc., est largement utilisé et a une valeur élevée.
(ZH) 本发明公开了一种以PX为原料合成对羟甲基苯甲酸的方法,PX溶解在有机溶剂中,在M-MOF催化剂作用下与氧化剂进行氧化反应,反应结束经后处理得到对羟甲基苯甲酸;所述M-MOF催化剂中金属元素M为Fe、Cu、Cr、Mn、Cu/Fe、Cu/Cr、Cu/Mn、Fe/Mn、Cr/Fe或Cr/Mn。本发明原料来源丰富,价格低廉;反应过程中产生的副产物少,产率高,分离方便;在反应过程中无需酸碱中和,减少了污染;本发明为一步反应,具有反应条件温和、反应时间短、污染低,便于工业化放大生产,制得的对羟甲基苯甲酸可用于制备药物、液晶材料等,用途十分广泛,价值较高。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)