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1. (WO2018227429) CRYSTAL TYPE II SUBSTANCE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
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Pub. No.: WO/2018/227429 International Application No.: PCT/CN2017/088251
Publication Date: 20.12.2018 International Filing Date: 14.06.2017
IPC:
C07D 295/21 (2006.01) ,A61K 31/495 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
295
Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
16
acylated on ring nitrogen atoms
20
by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
21
Radicals derived from sulfur analogues of carbonic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
北京大学 PEKING UNIVERSITY [CN/CN]; 中国北京市 海淀区学院路38号 No. 38, Xueyuan Road, Haidian District Beijing 100191, CN
Inventors:
李润涛 LI, Runtao; CN
吕扬 LV, Yang; CN
崔景荣 CUI, Jingrong; CN
杜冠华 DU, Guanhua; CN
葛泽梅 GE, Zemei; CN
杨世颖 YANG, Shiying; CN
Agent:
北京信慧永光知识产权代理有限责任公司 BEIJING SUNHOPE INTELLECTUAL PROPERTY LTD.; 中国北京市 海淀区知春路9号坤讯大厦1106室 Suite 1106, Kunxun Plaza, Zhichun Road 9, Haidian District Beijing 100191, CN
Priority Data:
Title (EN) CRYSTAL TYPE II SUBSTANCE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
(FR) SUBSTANCE CRISTALLINE II, SON PROCÉDÉ DE PRÉPARATION, SA COMPOSITION PHARMACEUTIQUE ET SES APPLICATIONS
(ZH) 一种晶II型物质及其制备方法、药物组合物与用途
Abstract:
(EN) Provided are a crystal type II substance of a compound A (chemical name:1-piperazine dithioformate-3-cyano-3,3-diphenylpropyl ester hydrochloride, a preparation method therefor, and pharmaceutical composition and application thereof in preparation of medicines for treating and preventing tumors.
(FR) Font l’objet de la présente invention une substance cristalline II d’un composé A (dont le nom chimique est : 1-pipérazine dithioformate-3-cyano-3,3-dibenzyl-isopropylester d’acide hydrochlorique), son procédé de préparation, sa composition pharmaceutique et ses applications dans la préparation d’un médicament pour le traitement et la prévention de tumeurs.
(ZH) 提供一种化合物A(化学名:1-哌嗪二硫代甲酸-3-氰基-3,3-二苯基丙酯盐酸盐)的晶II型物质及其制备方法、药物组合物与在制备用于治疗和预防肿瘤的药物中的用途。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)