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1. (WO2018227427) SUBSTITUTED BRIDGED DIAZEPANE DERIVATIVES AND USE THEREOF
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Pub. No.: WO/2018/227427 International Application No.: PCT/CN2017/088237
Publication Date: 20.12.2018 International Filing Date: 14.06.2017
IPC:
C07D 471/08 (2006.01) ,C07D 471/04 (2006.01) ,A61K 31/439 (2006.01) ,A61P 11/00 (2006.01) ,A61P 25/00 (2006.01) ,A61P 9/06 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
08
Bridged systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
439
the ring forming part of a bridged ring system, e.g. quinuclidine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
06
Antiarrhythmics
Applicants:
BAYER AKTIENGESELLSCHAFT [DE/DE]; Kaiser-Wilhelm-Allee 1 51373 Leverkusen, DE
BAYER PHARMA AKTIENGESELLSCHAFT [DE/DE]; Müllerstrasse 178 13353 Berlin, DE
BAYER HEALTHCARE CO. LTD. [CN/CN]; 7 Rong Jing Dong Jie Beijing Economic and Technological Development Area Beijing 100176, CN
Inventors:
DELBECK, Martina; DE
HAHN, Michael; DE
MÜLLER, Thomas; DE
LUSTIG, Klemens; DE
MOSIG, Johanna; DE
COLLINS, Karl; DE
NICOLAI, Janine; DE
BECK-BROICHSITTER, Moritz; DE
ALBUS, Udo; DE
GEHRING, Doris; DE
DANG, Hongkai; CN
YANG, Jianfei; CN
DUAN, Dehe; CN
CHEN, Denghui; CN
ROSENSTEIN, Björn; DE
Agent:
CHINA PATENT AGENT (H.K.) LTD.; 22/F., Great Eagle Center 23 Harbour Road Wanchai Hong Kong, CN
Priority Data:
Title (EN) SUBSTITUTED BRIDGED DIAZEPANE DERIVATIVES AND USE THEREOF
(FR) DÉRIVÉS DE DIAZÉPANE PONTÉS SUBSTITUÉS ET LEUR UTILISATION
Abstract:
(EN) The present application relates to novel imidazopyridinyl-or imidazopyrimidinyl-substituted, bridged 1,4-diazepane derivatives, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of respiratory disorders including, sleep-related respiratory disorders such as obstructive sleep apnoeas and central sleep apnoeas and snoring.
(FR) La présente invention concerne de nouveaux dérivés de 1, 4-diazépane pontés substitués par des imidazopyridinyle ou par des imidazopyrimidinyle, leurs procédés de préparation, leur utilisation seuls ou en combinaisons pour le traitement et/ou la prévention de maladies, et leur utilisation pour la préparation de médicaments pour le traitement et/ou la prévention de maladies, en particulier pour le traitement et/ou la prévention de troubles respiratoires y compris des troubles respiratoires liés au sommeil tels que l'apnée obstructive du sommeil et l'apnée centrale du sommeil ainsi que le ronflement.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)