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1. (WO2018227299) BIOMARKERS FOR WOUND HEALING
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Pub. No.: WO/2018/227299 International Application No.: PCT/CA2018/050720
Publication Date: 20.12.2018 International Filing Date: 14.06.2018
IPC:
G01N 33/48 (2006.01) ,G01N 33/53 (2006.01) ,G01N 33/543 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
543
with an insoluble carrier for immobilising immunochemicals
Applicants:
MCMASTER UNIVERSITY [CA/CA]; 305-175 Longwood Road South Hamilton, Ontario L8P 0A1, CA
UNIVERSITY OF WESTERN AUSTRALIA [AU/AU]; 35 Stirling Highway Crawley, Western Australia 6009, AU
Inventors:
STACEY, Michael; CA
PHILLIPS, Steven; CA
SWAIN, Jillian Marlene; AU
Agent:
TANDAN, Susan; CA
Priority Data:
62/519,47814.06.2017US
Title (EN) BIOMARKERS FOR WOUND HEALING
(FR) BIOMARQUEURS DE CICATRISATION DES PLAIES
Abstract:
(EN) A method for determining healing status of a wound is provided comprising: i) quantifying the expression level of GM-CSF or MMP-13, and optionally one or more additional biomarkers, in a wound tissue sample or wound fluid sample from a wound of a mammalian subject; and ii) comparing the expression level of GM-CSF or MMP- 13 of the wound tissue sample or wound fluid sample to a threshold level and determining that the wound is non-healing if the level of GM-CSF or MMP-13 exceeds the threshold level.
(FR) L'invention concerne un procédé de détermination de l'état de cicatrisation d'une plaie, comprenant : i) la quantification du le niveau d'expression du GM-CSF ou de la MMP -13, et éventuellement d'un ou plusieurs biomarqueurs supplémentaires, dans un échantillon de tissu de plaie ou un échantillon de fluide de plaie provenant d'une plaie d'un sujet mammifère ; et ii) la comparaison du niveau d'expression du GM-CSF ou de la MMP-13 de l'échantillon de tissu de plaie ou de l'échantillon de fluide de plaie à un niveau seuil et la détermination du fait que la plaie est non cicatrisante si le niveau de GM-CSF ou de MMP -13 dépasse le niveau seuil.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)