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1. (WO2018227231) NON-VIRAL GENE DELIVERY AGENT COMPRISING LIPOPEPTIDE (LP) COMPOUNDS
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Pub. No.: WO/2018/227231 International Application No.: PCT/AU2018/000093
Publication Date: 20.12.2018 International Filing Date: 08.06.2018
IPC:
A61K 48/00 (2006.01) ,A61K 38/08 (2006.01) ,A61K 47/10 (2017.01) ,A61K 47/42 (2017.01) ,A61K 47/14 (2017.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08
Peptides having 5 to 11 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
10
Alcohols; Phenols; Salts thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
42
Proteins; Polypeptides; Degradation products thereof; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
14
Esters of carboxylic acids
Applicants:
MONASH UNIVERSITY [AU/AU]; Wellington Road Clayton, Victoria 3800, AU
Inventors:
POUTON, Colin William; AU
HO, Kha Tu Joan; AU
WHITE, Paul James; AU
BUI, Catherine Thoa; AU
AKHTAR, Nabila; AU
AL-WASSITI, Hareth Ali; AU
Agent:
Madderns Patent & Trade Mark Attorneys; GPO Box 2752 Adelaide, 5001 South Australia, AU
Priority Data:
201790223813.06.2017AU
Title (EN) NON-VIRAL GENE DELIVERY AGENT COMPRISING LIPOPEPTIDE (LP) COMPOUNDS
(FR) AGENT NON VIRAL D'ADMINISTRATION DE GÈNE COMPRENANT DES COMPOSÉS LIPOPEPTIDIQUES (LP)
Abstract:
(EN) Non- viral nucleic acid delivery agents and methods for the delivery or transfer of nucleic acid molecules to target cells are disclosed. The agents comprise a complex of a nucleic acid cargo for delivery, one or more lipopeptide compound, and one or more polymeric charge-neutralising agent, and the complex is in the form of a particle with substantially neutral or negative surface charge. The agents and methods may be useful in a variety of applications such as therapies (including gene therapies and nucleic acid vaccinations) for diseases and medical disorders.
(FR) L'invention concerne des agents non viraux d'administration d'acides nucléiques et des méthodes destinées à l'administration ou au transfert de molécules d'acides nucléiques à des cellules cibles. Les agents comprennent un complexe constitué de la charge d'acide nucléique destinée à être administrée, d'un ou de plusieurs composés lipopeptidiques, et d'un ou de plusieurs agents polymériques de neutralisation de charge, et le complexe se présente sous la forme d'une particule ayant une charge de surface sensiblement neutre ou négative. Les agents et les méthodes peuvent servir à un grand nombre d'applications telles que des thérapies (notamment des thérapies géniques et des vaccinations par acides nucléiques) pour des maladies et des troubles médicaux.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)