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1. (WO2018226907) FACTORY-ON-A-CHIP FOR PRODUCTION OF BIOLOGICALLY DERIVED MEDICINES/BIOPHARMACEUTICALS/BIOLOGICS/ BIOTHERAPEUTICS
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Pub. No.: WO/2018/226907 International Application No.: PCT/US2018/036375
Publication Date: 13.12.2018 International Filing Date: 07.06.2018
IPC:
C12M 3/06 (2006.01) ,C12M 1/00 (2006.01) ,B01L 3/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3
Tissue, human, animal or plant cell, or virus culture apparatus
06
with filtration, ultrafiltration, inverse osmosis or dialysis means
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1
Apparatus for enzymology or microbiology
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
L
CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3
Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
Applicants:
UNIVERSITY OF MARYLAND, BALTIMORE COUNTRY [US/US]; Office Of Technology Development 1000 Hilltop Circle Baltimore, MD 21250, US
Inventors:
RAO, Govind; US
KOSTOV, Yordan; US
ANDAR, Abhay; US
AL-ADHAMI, Mustafa; US
Agent:
FUIERER, Marianne; US
Priority Data:
62/516,16107.06.2017US
Title (EN) FACTORY-ON-A-CHIP FOR PRODUCTION OF BIOLOGICALLY DERIVED MEDICINES/BIOPHARMACEUTICALS/BIOLOGICS/ BIOTHERAPEUTICS
(FR) USINE SUR PUCE POUR LA PRODUCTION DE MÉDICAMENTS/BIOPRODUITS/BIOPRODUITS BIOLOGIQUES/AGENTS BIOTHÉRAPEUTIQUES D'ORIGINE BIOLOGIQUE
Abstract:
(EN) The present invention provides for a fully integrated microfluidic system capable of producing single-dose amounts of biotherapeutics at the point-of-care wherein protein production, purification and product harvest are all integrated as a single microfluidic device which is portable and capable of continuous-flow production of biotherapeutics at the microscale using a cell-free reaction system.
(FR) La présente invention concerne un système microfluidique entièrement intégré permettant de produire des quantités à dose unique d'agents biothérapeutiques au niveau du point de soins, la production de protéines, la purification et la récolte de produits étant tous intégrés sous la forme d'un seul dispositif microfluidique qui est portable et permet de produire en continu des agents biothérapeutiques à l'échelle micrométrique à l'aide d'un système de réaction exempt de cellules.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)