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1. WO2018226769 - 1-(2-AZASPIRO[3.3]HEPTAN-6-YL)-5,6-DIHYDRO-4H-BENZO[F][1,2,4]TRIAZOLO[4,3-A][1,4]DIAZEPINE DERIVATIVES AS V1A RECEPTOR ANTAGONISTS FOR TREATING NEUROPSYCHOLOGICAL DISORDERS

Publication Number WO/2018/226769
Publication Date 13.12.2018
International Application No. PCT/US2018/036167
International Filing Date 05.06.2018
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
55
having seven-membered rings, e.g. azelastine, pentylenetetrazole
551
having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
5513
1,4-Benzodiazepines, e.g. diazepam
5517
condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
55
having seven-membered rings, e.g. azelastine, pentylenetetrazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
22
Anxiolytics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
20
Hypnotics; Sedatives
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
24
Antidepressants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
18
Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
06
Antiarrhythmics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15
Drugs for genital or sexual disorders; Contraceptives
10
for impotence
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15
Drugs for genital or sexual disorders; Contraceptives
08
for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
C07D 487/04 (2006.01)
C07D 491/04 (2006.01)
A61K 31/5517 (2006.01)
A61K 31/55 (2006.01)
A61P 25/22 (2006.01)
A61P 25/20 (2006.01)
CPC
A61P 15/08
A61P 15/10
A61P 25/18
A61P 25/20
A61P 25/22
A61P 25/24
Applicants
  • BLACKTHORN THERAPEUTICS, INC. [US/US]; 780 Brannan Street San Francisco, California 94103, US
Inventors
  • TIERNEY, Jason; GB
  • HARDICK, David; GB
  • URBANO, Mariangela; US
  • JONES, Robert, M.; US
  • BRANDT, Gary; US
  • KNIGHT, Chris; GB
Agents
  • COOPER, Michael, P.; US
  • OBEIDAT, Baha, A.; US
  • KUMABE, Blake, K.; US
  • SOLTANI, Bobby, B.; US
  • SARGEANT, Brooke; US
  • QUIST, Brooke, W.; US
  • ROTH, Carol, J.; US
  • EIDT, Chandra, E.; US
  • O'BRIEN, Daniel; US
  • CARLSON, David, V.; US
  • STARK, Duncan; US
  • TARLETON, E., Russell; US
  • SUN, Eileen, S.; US
  • HARWOOD, Eric, A.; US
  • ABRAMONTE, Frank; US
  • HAN, Hai; US
  • TALBERT, Hayley, J.; US
  • WHITE, James, A. D.; US
  • BARRETT, Jared, M.; US
  • PEPE, Jeffrey, C.; US
  • DANLEY, Jeffrey, E.; US
  • SAKOI, Jeffrey, M.; US
  • BAUNACH, Jeremiah, J.; US
  • KARLEN, John, R.; US
  • MORGAN, John, A.; US
  • WAKELEY, John, J.; US
  • COE, Justin, E.; US
  • HENCKEL, Karen, M.; US
  • HEFTER, Karl, A.; US
  • HERMANNS, Karl, R.; US
  • MORGAN, Kevan, L.; US
  • COSTANZA, Kevin, S.; US
  • LINFORD, Lorraine; US
  • RUSYN, Paul; US
  • LIN, Qing; US
  • HALLER, Rachel, A.; US
  • IANNUCCI, Robert; US
  • KOVELMAN, Robert, L.; US
  • WEBB, Samuel, E.; US
  • LEEK, Shoko, I.; US
  • ROSENMAN, Stephen, J.; US
  • ABEDI, Syed; US
  • SATAGAJ, Thomas, J.; US
  • BOLLER, Timothy, L.; US
  • LIGON, Toby, J.; US
  • FERRON, William, O., Jr.; US
  • ZENTZ, Bradley, J.; US
  • GERTZ, Glenda, A.; US
  • SHEWMAKE, Thomas, A.; US
  • CANTRELL, Tyler, C.; US
Priority Data
62/515,47305.06.2017US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 1-(2-AZASPIRO[3.3]HEPTAN-6-YL)-5,6-DIHYDRO-4H-BENZO[F][1,2,4]TRIAZOLO[4,3-A][1,4]DIAZEPINE DERIVATIVES AS V1A RECEPTOR ANTAGONISTS FOR TREATING NEUROPSYCHOLOGICAL DISORDERS
(FR) DÉRIVÉS DE 1-(2-AZASPIRO[3.3]HEPTAN-6-YL)-5,6-DIHYDRO-4H-BENZO[F][1,2,4]TRIAZOLO[4,3-A][1,4]DIAZÉPINE EN TANT QU'ANTAGONISTES DU RÉCEPTEUR V1A POUR LE TRAITEMENT DE TROUBLES NEUROPSYCHOLOGIQUES
Abstract
(EN)
Compounds of Formula (I) that antagonize vasopressin receptors, particularly the Via receptor. The compounds are useful for treating e.g. neuropsychological disorders, such as e.g. anxiety, depression and schizophrenia. Preferred compounds are e.g. 1-(2-azaspiro[3.3]heptan-6-yl)-5,6- dihydro-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine derivatives.
(FR)
La présente invention concerne des composés de formule (I) qui ont un effet antagoniste sur les récepteurs de la vasopressine, en particulier le récepteur V1a. Les composés sont utiles pour traiter, par exemple, des troubles neuropsychologiques, tels que l'anxiété, la dépression et la schizophrénie. Les composés préférés selon l'invention, sont par exemple des dérivés de 1-(2-azaspiro[3.3]heptan-6-yl)-5,6-dihydro-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazépine.
Also published as
EP2018734702
Latest bibliographic data on file with the International Bureau