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1. (WO2018226747) ERYTHROPOIETIN AND ANALOGS FOR VETERINARY USE
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Pub. No.: WO/2018/226747 International Application No.: PCT/US2018/036133
Publication Date: 13.12.2018 International Filing Date: 05.06.2018
IPC:
C07K 14/505 (2006.01) ,C07K 16/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
475
Growth factors; Growth regulators
505
Erythropoietin (EPO)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
Applicants:
KINDRED BIOSCIENCES, INC. [US/US]; 1555 Bayshore Highway Suite 200 Burlingame, California 94010, US
Inventors:
ZHAN, Hangjun; US
NGUYEN, Lam; US
LI, Yongzhong; US
CHU, Qingyi; US
GARCIA-MURILLO, Estela; US
LEITMAN, Victoria; US
SUNDLOF, Stephen; US
CHIN, Richard; US
LI, Shyr Jiann; US
Agent:
HENNINGER, Mary R.; US
SCARR, Rebecca; US
MCNEILL, Rebecca; US
BAUR, Amelia; US
DOHERTY, Elizabeth; US
KELLEY, Lara; US
BREIER, Adam; US
CHO, Hojung; US
PRYBYLOWSKI, Kate; US
HERZFELD, Deborah; US
SCHOENHARD, Amy; US
RACHINSKY, Tara; US
LEE, Victoria; US
Priority Data:
62/516,09206.06.2017US
62/516,64207.06.2017US
62/559,10415.09.2017US
Title (EN) ERYTHROPOIETIN AND ANALOGS FOR VETERINARY USE
(FR) ÉRYTHROPOÏÉTINE ET COMPOSÉS ANALOGUES À USAGE VÉTÉRINAIRE
Abstract:
(EN) Provided are various embodiments relating to feline erythropoietin (EPO) polypeptide analogs with one or more additional glycosylation sites and methods of producing and using the same to treat anemia in companion animals. Also provided are various embodiments relating to EPO polypeptides having a mutation in the second binding site, polypeptides comprising an extracellular domain of EPO receptor, and methods of using the same for treating polycythemia in mammals.
(FR) L'invention concerne divers modes de réalisation relatifs à des analogues polypeptidiques d'érythropoïétine (EPO) féline comprenant un ou plusieurs sites de glycosylation supplémentaires et des procédés de production et d'utilisation de ceux-ci pour traiter l'anémie chez des animaux de compagnie. L'invention concerne également divers modes de réalisation relatifs à des polypeptides d'EPO présentant une mutation dans le second site de liaison, des polypeptides comprenant un domaine extracellulaire du récepteur d'EPO, et des procédés d'utilisation de ceux-ci pour traiter la polyglobulie chez les mammifères.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)