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1. (WO2018226589) SMALL MOLECULE PROTEOSOME ACTIVATORS AND USES THEREOF
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Pub. No.: WO/2018/226589 International Application No.: PCT/US2018/035869
Publication Date: 13.12.2018 International Filing Date: 04.06.2018
IPC:
A61K 31/5415 (2006.01) ,C07D 279/14 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
54
having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
5415
ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
279
Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
10
1,4-Thiazines; Hydrogenated 1,4-thiazines
14
condensed with carbocyclic rings or ring systems
Applicants:
BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY [US/US]; 450 Administration Building East Lansing, Michigan 48824-1046, US
Inventors:
TEPE, Jetze J.; US
LANSDELL, Theresa A.; US
NJOMEN, Evert; US
JONES, Corey Lee; US
Agent:
PERDOK, Monique M.; US
ARORA, Suneel, Reg. No. 42,267; US
BEEKMAN, Marvin L.; US
BIANCHI, Timothy E., Reg. No. 39,610; US
BLACK, David W., Reg. No. 42,331; US
MCCRACKIN, Ann M., Reg. No. 42,858; US
SCHEER, Bradley W., Reg. No. 47,059; US
WOO, Justin N., Reg. No. 62,686; US
Priority Data:
62/515,40305.06.2017US
Title (EN) SMALL MOLECULE PROTEOSOME ACTIVATORS AND USES THEREOF
(FR) ACTIVATEURS DE PROTÉASOME À PETITES MOLÉCULES ET UTILISATIONS ASSOCIÉES
Abstract:
(EN) The disclosure is directed to compounds of the formula (I) and (II) and uses of such compounds to treat, among other conditions, neurodegenerative diseases and cancers.
(FR) L'invention concerne des composés de formule (I) et (II) et des utilisations de tels composés pour traiter, entre autres conditions, des maladies neurodégénératives et des cancers.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)