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1. (WO2018226578) NECTIN-4-BINDING PROTEINS AND METHODS OF USE THEREOF
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Pub. No.: WO/2018/226578 International Application No.: PCT/US2018/035840
Publication Date: 13.12.2018 International Filing Date: 04.06.2018
IPC:
C07K 16/28 (2006.01) ,C07K 16/40 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
40
against enzymes
Applicants:
AGENSYS, INC. [US/US]; 1800 Stewart Street Santa Monica, CA 90404, US
Inventors:
MORRISON, Karen Jane, Meyrick; US
DONATE, Fernando; US
YANG, Peng; US
Agent:
LIANG, Bing Liang; US
GEORGE, Nikolaos, C.; US
ANTLER, Adriane, M.; US
INSOGNA, Anthony, M.; US
ROWAN, Thomas, G.; US
Priority Data:
62/515,45405.06.2017US
Title (EN) NECTIN-4-BINDING PROTEINS AND METHODS OF USE THEREOF
(FR) PROTÉINES DE LIAISON À LA NECTINE-4 ET LEURS PROCÉDÉS D'UTILISATION
Abstract:
(EN) Provided herein are compositions, methods and uses involving antibodies that specifically bind to Nectin-4. Also provided herein are methods for assessing Nectin-4 expression in a sample or a patient and methods for assessing responsiveness of a cancer to an anti-cancer therapeutic agent.
(FR) L'invention concerne des compositions, des procédés et des utilisations faisant intervenir des anticorps qui se lient de manière spécifique à la nectine-4. L'invention concerne également des procédés d'évaluation de l'expression de la nectine-4 dans un échantillon ou chez un patient et des procédés d'évaluation de la réactivité d'un cancer à un agent thérapeutique anticancéreux.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)