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1. (WO2018226504) SEROLOGY ASSAY FOR RECENT MALARIA INFECTION
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Pub. No.: WO/2018/226504 International Application No.: PCT/US2018/035380
Publication Date: 13.12.2018 International Filing Date: 31.05.2018
IPC:
G01N 33/569 (2006.01) ,G01N 33/558 (2006.01) ,G01N 33/68 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
569
for micro-organisms, e.g. protozoa, bacteria, viruses
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
558
using diffusion or migration of antigen or antibody
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants:
TOKITAE LLC [US/US]; 3150 139th Ave SE Bellevue, Washington 98005-4046, US
LONDON SCHOOL OF HYGIENE & TROPICAL MEDICINE [GB/GB]; Keppel Street London WC1E 7HT, GB
Inventors:
CATE, David Michael; US
DRAKELEY, Christopher John; GB
GREENHOUSE, Bryan Ross; US
NICHOLS, Kevin Paul Flood; US
RODRIGUEZ-BARRAQUER, Isabel; US
TETTEH, Kevin Kweku Adjei; GB
WEIGL, Bernhard Hans; US
Agent:
MALASKA, Stephen L.; US
TEGREENE, Clarence T.; US
CHAN, Alistair K.; US
ROCHESTER, S. Craig; US
STEWART, John C.; US
Priority Data:
15/991,35529.05.2018US
62/515,23305.06.2017US
Title (EN) SEROLOGY ASSAY FOR RECENT MALARIA INFECTION
(FR) DOSAGE SÉROLOGIQUE POUR LE DÉPISTAGE D'UNE INFECTION PALUDÉENNE RÉCENTE
Abstract:
(EN) In some embodiments, an immunoassay device for detection of recent malaria infection includes: a sample pad positioned adjacent to a first end of a conjugate pad, wherein either the sample pad or the first end of the conjugate pad include a detection complex able to bind anti-ETRAMP5 antibodies; wherein a second end of the conjugate pad includes one or more areas impregnated with a construct protein including ETRAMP5 protein fragments. In some embodiments, the detection complex for anti-ETRAMP5 antibodies includes a capture particle complexed with anti-IgG antibodies. In some embodiments, the detection complex for anti-ETRAMP5 antibodies includes a detection particle complexed with a complex molecule including ETRAMP5 protein fragments.
(FR) Selon certains modes de réalisation, cette invention concerne un dispositif de dosage immunologique pour le dépistage d'une infection paludéenne récente comprenant : un tampon d'échantillon placé en une position adjacente à une première extrémité d'un tampon conjugué, où soit le tampon d'échantillon, soit ladite première extrémité du tampon conjugué comprend un complexe de détection capable de fixer des anticorps anti-ETRAMP5 ; la seconde extrémité du tampon conjugué comprenant une ou plusieurs zones imprégnées d'une protéine de construction comprenant des fragments de protéine ETRAMP5. Dans certains modes de réalisation, le complexe de détection d'anticorps anti-ETRAMP5 comprend une particule de capture complexée à des anticorps anti-IgG. Dans d'autres, le complexe de détection d'anticorps anti-ETRAMP5 comprend une particule de détection complexée à une molécule complexe comprenant des fragments de protéine ETRAMP5.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)