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1. (WO2018226267) LIVER ORGANOID COMPOSITIONS AND METHODS OF MAKING AND USING SAME
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Pub. No.: WO/2018/226267 International Application No.: PCT/US2018/018585
Publication Date: 13.12.2018 International Filing Date: 19.02.2018
IPC:
C12N 5/074 (2010.01) ,C12N 5/0789 (2010.01) ,C12N 5/095 (2010.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
074
Adult stem cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
078
Cells from blood or from the immune system
0789
Stem cells; Multipotent progenitor cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
09
Tumour cells
095
Stem cells; Progenitor cells
Applicants:
CHILDREN'S HOSPITAL MEDICAL CENTER [US/US]; 3333 Burnett Avenue Cincinnati, OH 45229, US
Inventors:
TAKEBE, Takanori; US
SHINOZAWA, Tadahiro; US
KOIKE, Hiroyuki; US
KIMURA, Masaki; US
Agent:
TEPE, Nicole, M.; US
SCHOEN, Ann, G.; US
CONLEY, Scott, R.; US
GOLDSTEIN, Steven, J.; US
ACHESON, Edwin, R.; US
Priority Data:
62/517,41409.06.2017US
Title (EN) LIVER ORGANOID COMPOSITIONS AND METHODS OF MAKING AND USING SAME
(FR) COMPOSITIONS D'ORGANOÏDES HÉPATIQUES ET PROCÉDÉS DE PRÉPARATION ET D'UTILISATION CORRESPONDANTS
Abstract:
(EN) Disclosed are methods of inducing formation of a liver organoid from precursor cells, such as iPSC cells. The disclosed liver organoids may be used for screening for a serious adverse event (SAE), such as liver failure and/or drug induced liver injury (DILI), and/or drug toxicity. The disclosed liver organoids may also be used to treat an individual having liver damage, or for identifying a preferred therapeutic agent.
(FR) L'invention concerne des procédés destinés à induire la formation d'un organoïde hépatique à partir de cellules précurseurs, telles que des cellules iPSC. Les organoïdes hépatiques selon l'invention peuvent être utilisés pour dépister un événement indésirable grave (EIG), tel qu'une insuffisance hépatique et/ou une atteinte hépatique médicamenteuse (DILI), et/ou une toxicité médicamenteuse. Les organoïdes hépatiques selon l'invention peuvent également être utilisés pour traiter un individu présentant une lésion hépatique, ou pour identifier un agent thérapeutique préféré.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)