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1. (WO2018225907) METHOD FOR PREPARING INJECTABLE ADHESIVE COMPOSITION FOR FIXING BONE GRAFT MATERIAL, AND INJECTABLE ADHESIVE COMPOSITION FOR FIXING BONE GRAFT MATERIAL PREPARED THEREFROM
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Pub. No.: WO/2018/225907 International Application No.: PCT/KR2017/012248
Publication Date: 13.12.2018 International Filing Date: 01.11.2017
IPC:
A61L 24/00 (2006.01) ,A61L 24/08 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
24
Surgical adhesives or cements; Adhesives for colostomy devices
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
24
Surgical adhesives or cements; Adhesives for colostomy devices
04
containing macromolecular materials
08
Polysaccharides
Applicants:
주식회사 티앤알바이오팹 T & R BIOFAB CO., LTD. [KR/KR]; 경기도 시흥시 산기대학로 237, 540호 540, 237 Sangidaehak-ro Siheung-si Gyeonggi-do 15073, KR
부산대학교 산학협력단 PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION [KR/KR]; 부산시 금정구 부산대학로63번길 2 2, Busandaehak-ro 63beon-gil Geumjeong-gu Busan 46241, KR
Inventors:
최다미 CHOI, Da Mi; KR
심진형 SHIM, Jin Hyung; KR
허중보 HUH, Jung Bo; KR
김창환 KIM, Chang Hwan; KR
안근선 AHN, Geun Seon; KR
윤원수 YUN, Won Soo; KR
Agent:
윤병국 YOON, Byong Kuk; 서울시 강남구 테헤란로 108길 11, 3층 (대치동, 삼호빌딩) (Samho Bldg., Daechi-dong) 3rd Fl., 11, Teheran-ro 108-gil Gangnam-gu Seoul 06175, KR
이영규 LEE, Young Kyu; 서울시 강남구 테헤란로 108길 11, 3층 (대치동, 삼호빌딩) (Samho Bldg., Daechi-dong) 3rd Fl., 11, Teheran-ro 108-gil Gangnam-gu Seoul 06175, KR
소재현 SO, Jae Hyun; 서울시 강남구 테헤란로 108길 11, 3층 (대치동, 삼호빌딩) (Samho Bldg., Daechi-dong) 3rd Fl., 11, Teheran-ro 108-gil Gangnam-gu Seoul 06175, KR
Priority Data:
10-2017-006982305.06.2017KR
Title (EN) METHOD FOR PREPARING INJECTABLE ADHESIVE COMPOSITION FOR FIXING BONE GRAFT MATERIAL, AND INJECTABLE ADHESIVE COMPOSITION FOR FIXING BONE GRAFT MATERIAL PREPARED THEREFROM
(FR) PROCÉDÉ DE PRÉPARATION D'UNE COMPOSITION ADHÉSIVE INJECTABLE POUR FIXER UN MATÉRIAU DE GREFFE OSSEUSE ET COMPOSITION ADHÉSIVE INJECTABLE POUR FIXER UN MATÉRIAU DE GREFFE OSSEUSE PRÉPARÉ À PARTIR DE CELLE-CI
(KO) 골 이식재 고정용 주사형 접착제 조성물의 제조방법 및 이를 통해 제조된 골 이식재 고정용 주사형 접착제 조성물
Abstract:
(EN) The present invention relates to a method for preparing an injectable adhesive composition for fixing a bone graft material, which fixes a bone graft material or a shielding membrane that are filled in the body in order to restore defective parts in bone tissues, and an injectable adhesive composition for fixing a bone graft material prepared by the same method. As the injectable adhesive composition comprises a decellularized extracellular matrix (dECM) having excellent biocompatibility and a calcium phosphate compound having similar inorganic ingredients as those of bone tissues, the injectable adhesive composition has advantages in that the decellularized extracellular matrix undergoes a gelation reaction due to a protein component such as collagen at a temperature similar to body temperature, thereby being capable of fixing a bone graft material and a shielding membrane through physical fibrosis when inserted into the body, and also the decellularized extracellular matrix is completely dissolved and absorbed in the body without any foreign body reaction after a certain period of time, thereby requiring no secondary removal procedure.
(FR) La présente invention concerne un procédé de préparation d'une composition adhésive injectable pour fixer un matériau de greffe osseuse, qui fixe un matériau de greffe osseuse ou une membrane de protection qui sont introduits dans le corps afin de restaurer des parties déficientes dans des tissus osseux, et une composition adhésive injectable pour fixer un matériau de greffe osseuse préparé par le même procédé. Comme la composition adhésive injectable comprend une matrice extracellulaire décellularisée (MECd) présentant une excellente biocompatibilité et un composé de type phosphate de calcium présentant des ingrédients inorganiques similaires à ceux des tissus osseux, la composition adhésive injectable présente des avantages en ce que la matrice extracellulaire décellularisée subit une réaction de gélification due à un constituant protéique, tel que le collagène, à une température similaire à la température corporelle, ce qui permet de fixer un matériau de greffe osseuse et une membrane de protection par l'intermédiaire d'une fibrose physique lorsqu'ils sont introduits dans le corps et la matrice extracellulaire décellularisée est également complètement dissoute et absorbée dans le corps sans aucune réaction de corps étranger après une certaine période de temps, ne nécessitant ainsi pas de procédure d'élimination secondaire.
(KO) 본 발명은, 골 조직의 결손부의 복원을 위하여 체내에 충진되는 골 이식재 또는 차폐막을 고정시키기 위한 골 이식재 고정용 주사형 접착제 조성물의 제조방법 및 이러한 방법으로 제조된 골 이식재 고정용 주사형 접착제 조성물에 관한 것으로, 생체 친화성이 우수한 탈세포화 세포 외 기질 (decellularized extracellular matrix, dECM)과 골 조직과 무기 성분이 유사한 인산칼슘 화합물을 포함하여, 탈세포화 세포 외 기질은 콜라겐 등과 같은 단백질 성분으로 인해 체온과 유사한 온도에서 겔화 반응을 일으켜 체내에 삽입시 물리적인 섬유화를 통해 골이식재 및 차폐막을 고정시킬 수 있을 뿐 만 아니라, 일정 기간이 경과 후 체내에 이물반응 없이 완전히 분해 및 흡수되어 2차 제거 시술이 필요하지 않는 장점이 있다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)