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1. (WO2018225848) COMPOSITION FOR PREVENTING OR TREATING SEPSIS
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Pub. No.: WO/2018/225848 International Application No.: PCT/JP2018/021966
Publication Date: 13.12.2018 International Filing Date: 08.06.2018
IPC:
A61K 33/42 (2006.01) ,A61P 31/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33
Medicinal preparations containing inorganic active ingredients
42
Phosphorus; Compounds thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
Applicants:
リジェンティス株式会社 REGENETISS INC. [JP/JP]; 長野県岡谷市川岸西1丁目4番1号 1-4-1 Kawagishinishi, Okaya-shi Nagano 3940046, JP
Inventors:
柴 肇一 SHIBA Toshikazu; JP
真鍋 厚史 MANABE Atsufumi; JP
沼澤 聡 NUMAZAWA Satoshi; JP
川添 祐美 KAWAZOE Yumi; JP
Agent:
石川 徹 ISHIKAWA Toru; JP
岡田 希子 OKADA Noriko; JP
Priority Data:
2017-11464709.06.2017JP
Title (EN) COMPOSITION FOR PREVENTING OR TREATING SEPSIS
(FR) COMPOSITION POUR LA PRÉVENTION OU LE TRAITEMENT DE LA SEPSIE
(JA) 敗血症の予防又は治療用組成物
Abstract:
(EN) The purpose of the present invention is to provide a composition for preventing or treating sepsis and various symptoms associated therewith (septic shock, disseminated intravascular coagulation syndrome, adult respiratory distress syndrome, multiple organ dysfunction syndrome, etc.). Provided is a composition for preventing or treating sepsis, said composition comprising, as an active ingredient, a condensed phosphoric acid such as polyphosphoric acid, metaphosphoric acid or ultraphosphoric acid or a salt thereof. In the condensed phosphoric acid, the average degree of phosphoric acid polymerization is preferably 2-1,500 in terms of PO3-. The composition is administered to patients in the dosage form of an injection, transfusion, oral preparation, etc.
(FR) L'objectif de la présente invention est de fournir une composition pour prévenir ou traiter la sepsie et divers symptômes associés à cette dernière (choc septique, syndrome de coagulation intravasculaire disséminée, syndrome de détresse respiratoire de l'adulte, syndrome de défaillance multiviscérale, etc.). L'invention concerne une composition pour la prévention ou le traitement de la sepsie, ladite composition comprenant, en tant que principe actif, un acide phosphorique condensé tel que l'acide polyphosphorique, l'acide métaphosphorique ou l'acide ultraphosphorique, ou un sel de ces derniers. L'acide phosphorique condensé présente un degré moyen de polymérisation de l'acide phosphorique compris de préférence entre 2 et 1 500 en termes de PO3 -. La composition est administrée aux patients sous la forme posologique d'une injection, d'une transfusion, d'une préparation orale, etc.
(JA) 敗血症及びそれに伴われる諸症状(敗血症性ショック、播種性血管内凝固症候群、成人呼吸窮迫症候群、多臓器機能障害等)の予防又は治療用組成物を提供することを目的として、ポリリン酸、メタリン酸若しくはウルトラリン酸のような縮合リン酸又はその塩を有効成分として含む敗血症の予防又は治療用組成物を提供する。ここで、縮合リン酸の平均リン酸重合度は、PO3を単位として2乃至1,500であることが好ましい。また、前記組成物は、注射剤、輸液、経口剤等の剤形で患者に投与される。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)