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1. (WO2018225623) LACTASE BULK POWDER AND LACTASE PREPARATION
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Pub. No.: WO/2018/225623 International Application No.: PCT/JP2018/021025
Publication Date: 13.12.2018 International Filing Date: 31.05.2018
IPC:
C12N 9/24 (2006.01) ,A23L 33/125 (2016.01) ,A61K 38/46 (2006.01) ,A61P 1/12 (2006.01) ,A61P 1/14 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
24
acting on glycosyl compounds (3.2)
[IPC code unknown for A23L 33/125]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43
Enzymes; Proenzymes; Derivatives thereof
46
Hydrolases (3)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
12
Antidiarrhoeals
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
14
Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
Applicants:
天野エンザイム株式会社 AMANO ENZYME INC. [JP/JP]; 愛知県名古屋市中区錦1丁目2番7号 2-7, Nishiki 1-chome, Naka-ku, Nagoya-shi, Aichi 4608630, JP
Inventors:
黒田 学 KURODA, Manabu; JP
北條 真之 HOJO, Masayuki; JP
Agent:
田中 順也 TANAKA, Junya; JP
水谷 馨也 MIZUTANI, Keiya; JP
迫田 恭子 SAKODA, Kyoko; JP
Priority Data:
2017-11284807.06.2017JP
Title (EN) LACTASE BULK POWDER AND LACTASE PREPARATION
(FR) POUDRE DE LACTASE EN VRAC ET PRÉPARATION DE LACTASE
(JA) ラクターゼ原末及びラクターゼ製剤
Abstract:
(EN) Provided are a lactase bulk powder and a lactase preparation both having improved storage stability. The stability of a lactase bulk powder is improved by regulating the acceptable amount of glucose and/or galactose, which are inevitably generated during manufacturing the lactase bulk powder, within a preset range. The lactase bulk powder comprises lactase, galactose and/or glucose, wherein the total amount of galactose and glucose is more than 0 μmol and not more than 50 μmol per 100,000 U of lactase; and the lactase preparation comprises the lactase bulk powder as an active ingredient.
(FR) L'invention concerne une poudre de lactase en vrac et une préparation de lactase présentant toutes deux une stabilité au stockage améliorée. La stabilité d'une poudre de lactase en vrac est améliorée par la régulation de la quantité acceptable de glucose et/ou de galactose, qui sont inévitablement produits pendant la fabrication de la poudre de lactase en vrac, afin qu'elle s'inscrive au sein d'une plage prédéfinie. La poudre de lactase en vrac comprend de la lactase, du galactose et/ou du glucose, la quantité totale de galactose et de glucose étant supérieure à 0 μmol et inférieure ou égale à 50 μmol pour 100 000 U de lactase ; et la préparation de lactase comprenant la poudre de lactase en vrac comme principe actif.
(JA) 保存安定性をより向上させたラクターゼ原末及びラクターゼ製剤を提供する。ラクターゼ原末の製造工程で不可避的に生じるグルコース及び/又はガラクトースの量の許容量を所定範囲内とすることで、ラクターゼ原末の安定性を向上させる。ラクターゼと、ガラクトース及び/又はグルコースとを含み、前記ガラクトース及び前記グルコースの総量が、ラクターゼ10万単位当たり0μmol超50μmol以下である、ラクターゼ原末;及び当該ラクターゼ原末を有効成分として含むラクターゼ製剤。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)