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1. (WO2018225086) METHOD AND DEVICE FOR RAPID DETECTION OF HEARNPV
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Pub. No.: WO/2018/225086 International Application No.: PCT/IN2018/050365
Publication Date: 13.12.2018 International Filing Date: 06.06.2018
IPC:
C12Q 1/68 (2018.01) ,C12Q 1/70 (2006.01) ,C07D 209/82 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
70
involving virus or bacteriophage
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
56
Ring systems containing three or more rings
80
[b, c]- or [b, d]-condensed
82
Carbazoles; Hydrogenated carbazoles
Applicants:
INDIAN INSTITUTE OF SCIENCE [IN/IN]; Bangalore, Karnataka, 560012, IN
ICAR - NATIONAL BUREAU OF AGRICULTURAL INSECT RESOURCES (NBAIR) [IN/IN]; P.B.No 2491, H.A. Farm Post, Bellary Road, Bangalore, Karnataka, 560 024, IN
Inventors:
BHATTACHARYA, Santanu; IN
DEY, Nilanjan; IN
BHAGAT, Deepa; IN
Agent:
BHATTA, Narendra Hosakere Lakshminarayana; IN
Priority Data:
20174101979006.06.2017IN
Title (EN) METHOD AND DEVICE FOR RAPID DETECTION OF HEARNPV
(FR) PROCÉDÉ ET DISPOSITIF DE DÉTECTION RAPIDE DU HEARNPV
Abstract:
(EN) The invention provides a method for obtaining a compound specific for rapid detection of HearNPV. The method includes obtaining a bromide precursor, 9-(4-bromobutyl)-9H-carbazole and constituting the bromide precursor in acetonitrile at a predefined temperature to obtain a piperazine derivative, 9-(4-(4-methylpiperazin-1-yl) butyl)-9H-carbazole. Subsequent to obtaining the piperazine derivative, the piperazine is reacted to obtain an intermediate aldehyde derivative, 9-(4-(4-methylpiperazin-1-yl)butyl)-9H- carbazole-3,6-dicarbaldehyde. The aldehyde derivative is further refluxed to obtain a carbazole derivative 3, 6 -di(1H-benzo [d]imidazol-2-yl)-9-(4-(4- methylpiperazin-1-yl)butyl)-9H-carbazole. Further, the invention provides a method for obtaining a probe for rapid detection for HearNPV. The method includes selecting a carbazole derivative 3, 6 -di(1H-benzo [d]imidazol-2-yl)-9-(4-(4-methylpiperazin-1- yl)butyl)-9H-carbazole, constituting the carbazole derivative in an organic medium and embedding the constituted carbazole derivative onto a substrate to obtain the probe. The invention also provides a device comprising a probe, a detection means and an analyser for rapid detection of HearNPV.
(FR) L'invention concerne un procédé d'obtention d'un composé spécifique destiné à la détection rapide du HearNPV. Le procédé consiste à obtenir un précurseur bromure, le 9-(4-bromobutyl)-9H-carbazole et à former le précurseur bromure dans de l'acétonitrile à une température prédéfinie pour obtenir un dérivé de pipérazine, le 9-(4-(4-méthylpipérazin-1-yl) butyl)-9H-carbazole. Après obtention du dérivé de pipérazine, la pipérazine est mise à réagir pour obtenir un dérivé d'aldéhyde intermédiaire, le 9-(4-(4-méthylpipérazin-1-yl)butyl)-9H- carbazole-3,6-dicarbaldéhyde. Le dérivé d'aldéhyde est en outre traité par reflux pour obtenir un dérivé de carbazole, le 3,6-di(1H-benzo[d]imidazol-2-yl)-9-(4-(4- méthylpipérazin-1-yl)butyl)-9H-carbazole. En outre, l'invention concerne un procédé d'obtention d'une sonde destinée à une détection rapide du HearNPV. Le procédé consiste à sélectionner un dérivé de carbazole, le 3,6-di(1H-benzo[d]imidazol-2-yl)-9-(4-(4-méthylpipérazin-1-yl)butyl)-9H-carbazole, à former le dérivé carbazole dans un milieu organique et à incorporer le dérivé de carbazole formé à un substrat pour obtenir la sonde. L'invention concerne également un dispositif comprenant une sonde, un moyen de détection et un analyseur destinés à la détection rapide du HearNPV.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)