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1. WO2018224563 - INHIBITORS OF RAC1 AND USES THEREOF FOR TREATING CANCERS

Publication Number WO/2018/224563
Publication Date 13.12.2018
International Application No. PCT/EP2018/064928
International Filing Date 06.06.2018
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
311
Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
15
Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
21
having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
311
Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
30
Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
37
having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
38
having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
44
having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
04
specific for metastasis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
63
Compounds containing para-N-benzene- sulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonohydrazide
C07C 311/21 (2006.01)
C07C 311/44 (2006.01)
A61P 35/04 (2006.01)
A61K 31/63 (2006.01)
CPC
C07C 311/21
C07C 311/44
Applicants
  • INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) [FR/FR]; 101, Rue de Tolbiac 75013 PARIS, FR
  • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE [FR/FR]; 3, rue Michel Ange 75016 PARIS, FR
  • UNIVERSITE DE NANTES [FR/FR]; 1, quai de Tourville 44000 NANTES, FR
  • CHU NANTES [FR/FR]; DIRECTION GENERALE 5 allée de l'île Gloriette 44000 NANTES, FR
Inventors
  • SAUZEAU, Vincent; FR
  • LOIRAND, Gervaise; FR
  • LEBRETON, Jacques; FR
  • TESSIER, Arnaud; FR
  • QUEMENER, Agnès; FR
Agents
  • HABASQUE, Etienne; FR
  • BLOT, Philippe; FR
  • HOLTZ, Béatrice; FR
  • COLOMBIE, Damien; FR
  • DOMENEGO, Bertrand; FR
  • NEYRET, Daniel; FR
Priority Data
17305664.906.06.2017EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INHIBITORS OF RAC1 AND USES THEREOF FOR TREATING CANCERS
(FR) INHIBITEURS DE RAC1 ET LEURS UTILISATIONS DANS LE TRAITEMENT DE CANCERS
Abstract
(EN)
The present invention concerns a compound having the following formula (I): wherein: - A is in particular -N(R'a)-C(=O)-R, R'a being H or a (C1-C6)alkyl group, and R being preferably a group having the following formula (II): - X is in particular chosen from the group consisting of: -SO2-N(R'b)-, R'b being H or a (C1-C6)alkyl group, -N(R"b)-SO2-, R"b being H or a (C1-C6)alkyl group, -CO-NH-, and -NH-CO-, for use for the treatment of cancers, such as metastatic cancers.
(FR)
La présente invention concerne un composé ayant la formule suivante (I) : dans laquelle : - A est en particulier -N(R'a)-C(=O)-R, R'a étant H ou un groupe alkyle en (C1-C6), et R étant de préférence un groupe ayant la formule suivante (II) : - X est en particulier choisi dans le groupe constitué par : -SO2-N(R'b)-, R'b étant H ou un groupe alkyle en (C1-C6), -N(R"b)-SO2-, R"b étant H ou un groupe alkyle en (C1-C6), -CO-NH- et -NH-CO-, le composé de l'invention étant destiné à être utilisé dans le traitement de cancers, tels que des cancers métastatiques.
Also published as
EP2018728643
Latest bibliographic data on file with the International Bureau