Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2018224016) USE OF BERBERINE OR DERIVATIVE THEREOF IN PREPARING MYOCARDIAL PERFUSION IMAGING AGENT
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/224016 International Application No.: PCT/CN2018/090295
Publication Date: 13.12.2018 International Filing Date: 07.06.2018
IPC:
A61K 51/04 (2006.01) ,A61K 101/02 (2006.01) ,C07D 455/03 (2006.01) ,A61K 31/4375 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
02
characterised by the carrier
04
Organic compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
101
Radioactive non-metals
02
Halogens
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
455
Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
03
containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
4375
the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
Applicants:
四川大学华西医院 WEST CHINA HOSPITAL, SICHUAN UNIVERSITY [CN/CN]; 中国四川省成都市 武侯区国学巷37号 No. 37, Guoxue Xiang, Wuhou District Chengdu, Sichuan 610041, CN
Inventors:
范成中 FAN, Chengzhong; CN
吴小艾 WU, Xiaoai; CN
梁梦 LIANG, Meng; CN
梅小莉 MEI, Xiaoli; CN
张彤 ZHANG, Tong; CN
王让 WANG, Rang; CN
陈皓田 CHEN, Haotian; CN
Agent:
成都高远知识产权代理事务所(普通合伙) GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP); 中国四川省成都市 高新区衣冠庙邮局A-42号信箱 The Yiguanmiao Post Office Box A-42 Hi-Tech Zone Chengdu, Sichuan 610041, CN
Priority Data:
201710433089.409.06.2017CN
Title (EN) USE OF BERBERINE OR DERIVATIVE THEREOF IN PREPARING MYOCARDIAL PERFUSION IMAGING AGENT
(FR) UTILISATION DE BERBÉRINE OU D'UN DÉRIVÉ DE CELLE-CI DANS LA PRÉPARATION D'UN AGENT D'IMAGERIE DE PERFUSION MYOCARDIQUE
(ZH) 黄连素或其衍生物在制备心肌灌注显像剂中的用途
Abstract:
(EN) Disclosed is the use of berberine or a derivative thereof in preparing a myocardial perfusion imaging agent, specifically the use of 18F-labelled berberine or a derivative thereof in preparing a myocardial perfusion imaging agent. In vitro studies, in vivo biodistribution and PET dynamic imaging for small animals verify that the fluoro-18-labelled berberine derivative can specifically aggregate in myocardial cells or the heart tissue; has good myocardial targeting distribution characteristics in living animals, such that the heart/surrounding tissue (liver, lung, blood, muscle, bone, etc.) contrast value is high; and can be used as a PET myocardial perfusion imaging agent.
(FR) La présente invention concerne l'utilisation de la berbérine ou d'un dérivé de celle-ci dans la préparation d'un agent d'imagerie de perfusion myocardique, en particulier l'utilisation de la berbérine marquée au 18F ou d'un dérivé de celle-ci dans la préparation d'un agent d'imagerie de perfusion myocardique. Des études in vitro, une biodistribution in vivo et une imagerie dynamique en TEP pour des petits animaux permettent de vérifier que le dérivé de berbérine marqué au fluor-18 peut s'agréger spécifiquement dans des cellules myocardiques ou dans le tissu cardiaque; a de bonnes caractéristiques de distribution de ciblage du myocarde chez les animaux vivants, de sorte que le cœur et les tissus environnants (foie, poumon, sang, muscle, os, etc.) présentent une valeur de contraste élevée; et peut être utilisé en tant qu'agent d'imagerie de perfusion myocardique en PET.
(ZH) 黄连素或其衍生物在制备心肌灌注显像剂中的用途, 18F标记的黄连素或其衍生物在制备心肌灌注显像剂中的用途。从体外研究、体内生物分布及小动物PET动态显像等方面验证了氟18标记的黄连素衍生物可特异性聚集于心肌细胞或心脏组织,在活体动物体内具有良好的心肌靶向分布特性,心脏/周围组织对比(肝、肺、血液、肌肉、骨骼等)值较高,可以作为一种PET心肌灌注显像剂。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)