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1. (WO2018223843) SYSTEM FOR DNA EDITING AND APPLICATION THEREOF

Pub. No.:    WO/2018/223843    International Application No.:    PCT/CN2018/088105
Publication Date: Fri Dec 14 00:59:59 CET 2018 International Filing Date: Fri May 25 01:59:59 CEST 2018
IPC: C12N 15/113
C12N 15/63
C12N 9/22
Applicants: GUANGZHOU RIBOBIO CO., LTD.
广州市锐博生物科技有限公司
Inventors: ZHANG, Biliang
张必良
Title: SYSTEM FOR DNA EDITING AND APPLICATION THEREOF
Abstract:
Provided is a system for DNA editing, comprising crRNA and tracrRNA. The crRNA is an RNA shown in formula I: Nx-ncrRNA (formula I), wherein the Nx is a spacer, and the ncrRNA is an RNA shown in SEQ ID NOs. 1-4 of the Sequence Listing. The tracrRNA is an RNA shown in SEQ ID NOs. 5-8 of the Sequence Listing.