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1. (WO2018223122) HDAC3-SELECTIVE INHIBITORS

Pub. No.:    WO/2018/223122    International Application No.:    PCT/US2018/035837
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Tue Jun 05 01:59:59 CEST 2018
IPC: A61K 31/404
A61P 35/00
C07D 209/12
Applicants: OHIO STATE INNOVATION FOUNDATION
ACADEMIA SINICA
Inventors: CHEN, Ching-Shih
HSIEH, Hao-Yu
CHUANG, Hsiao-Ching
Title: HDAC3-SELECTIVE INHIBITORS
Abstract:
Disclosed herein are selective HDAC inhibitors. In some embodiments, the compounds are selective HDAC3 inhibitors. The compounds are useful to treat a variety of conditions, including cancers, i.e., breast cancer, cachexia, and liver steatosis.