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1. (WO2018223121) PREDICTING CANCER TREATMENT OUTCOME WITH T-DM1

Pub. No.:    WO/2018/223121    International Application No.:    PCT/US2018/035836
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Tue Jun 05 01:59:59 CEST 2018
IPC: A61K 31/395
A61K 31/4015
A61K 31/4025
A61K 39/395
C07K 16/28
Applicants: EXPRESSION PATHOLOGY, INC.
MEMORIAL SLOAN-KETTERING CANCER CENTER
Inventors: HEMBROUGH, Todd
CECCHI, Fabiola
SCHWARTZ, Sarit
SCALTRITI, Maurizio
LI, Bob T.
Title: PREDICTING CANCER TREATMENT OUTCOME WITH T-DM1
Abstract:
Improved methods for treating lung cancer are provided. Tumor samples from patients are analyzed (i) by DNA sequencing to detect the presence of HER2 mutations and (ii) by mass spectrometric proteomic analysis to determine whether HER2 protein is expressed in the tumor cells. Patients respond to therapy with trastuzumab emtansine (T- DM1) or an equivalent antibody-drug conjugate when unique HER2 protein fragments are detected in the patient's tumor cells that harbor HER2 mutations. Conversely, patients do not respond to T-DM1 therapy when the tumor cells contain HER2 mutations but the unique protein fragments are not detected. Detection of HER3 in the tumor cells is a positive predictor of response to treatment.