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1. (WO2018223103) COMPOSITIONS AND METHODS FOR TUMOR VACCINATION AND IMMUNOTHERAPY INVOLVING HER ANTIGENS

Pub. No.:    WO/2018/223103    International Application No.:    PCT/US2018/035759
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Sun Jun 03 01:59:59 CEST 2018
IPC: A61K 39/12
A61K 35/76
A61K 39/39
A61K 39/395
A61K 45/06
A61K 47/68
Applicants: ETUBICS CORPORATION
Inventors: JONES, Frank R.
BALINT, Joseph
GABITZSCH, Elizabeth
Title: COMPOSITIONS AND METHODS FOR TUMOR VACCINATION AND IMMUNOTHERAPY INVOLVING HER ANTIGENS
Abstract:
In certain embodiments, methods and compositions are provided for generating immune responses against tumor antigens such as antigens or epitopes of HER1, HER2/neu, HER3, HER4, or any combination thereof. In particular embodiments, there may be provided methods for constructing and producing recombinant adenovirus-based vector vaccines containing nucleic acid sequences encoding tumor antigens such as antigens or epitopes of HER1, HER2/neu, HER3, HER4, or any combination thereof, that allow for vaccinations in individuals with preexisting immunity to adenovirus.