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1. (WO2018223078) SYSTEMS AND METHODS FOR DESIGNING SYNTHETIC ANTIMICROBIAL PEPTIDES
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Pub. No.: WO/2018/223078 International Application No.: PCT/US2018/035718
Publication Date: 06.12.2018 International Filing Date: 01.06.2018
IPC:
C07K 14/32 (2006.01)
[IPC code unknown for C07K 14/32]
Applicants:
UNIVERSITY OF NOTRE DAME DU LAC [US/US]; 1400 East Angela Blvd. South Bend, IN 46617, US
Inventors:
FIELDS, Francisco R.; US
LEE, Shaun W.; US
Agent:
STRINGHAM, John C.; US
NORTON, Jordan Paul; US
Priority Data:
62/513,46201.06.2017US
Title (EN) SYSTEMS AND METHODS FOR DESIGNING SYNTHETIC ANTIMICROBIAL PEPTIDES
(FR) SYSTÈMES ET PROCÉDÉS DE CONCEPTION DE PEPTIDES ANTIMICROBIENS SYNTHÉTIQUES
Abstract:
(EN) Methods for generating synthetic antimicrobial peptides include (i) identifying a peptide fragment of an antimicrobial peptide that includes a cluster of cationic residues and at least about 25% hydrophobic residues, preferably between about 40% – 60% hydrophobic residues and (ii) generating a peptide variant library based on the peptide fragment by varying a hydrophobicity and charge of residues that make up the peptide fragment. Resulting synthetic peptides can include linear synthetic peptide variants of an AS-48-like bacteriocin having increased antimicrobial activity.
(FR) Cette invention concerne des procédés de génération de peptides antimicrobiens synthétiques comprenant (i) l'identification d'un fragment peptidique de peptide antimicrobien qui contient un groupe de résidus cationiques et au moins environ 25 % de résidus hydrophobes, de préférence entre environ 40 et 60 % de résidus hydrophobes et (ii) la génération d'une banque de variants peptidiques sur la base dudit fragment peptidique par variation du caractère hydrophobe et de la charge des résidus constituant le fragment peptidique. Les peptides synthétiques obtenus peuvent comprendre des variants peptidiques synthétiques linéaires d'une bactériocine de type AS-48 ayant une activité antimicrobienne accrue.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)