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1. (WO2018223040) METHODS OF TREATING A TUMOR USING AN ANTI-PD-1 ANTIBODY

Pub. No.:    WO/2018/223040    International Application No.:    PCT/US2018/035670
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Sat Jun 02 01:59:59 CEST 2018
IPC: C07K 16/28
A61K 39/00
A61K 39/395
Applicants: BRISTOL-MYERS SQUIBB COMPANY
Inventors: EDWARDS, Robin
GEESE, William J.
GREENAWALT, Danielle M.
Title: METHODS OF TREATING A TUMOR USING AN ANTI-PD-1 ANTIBODY
Abstract:
This disclosure provides a method for treating a subject afflicted with tumor, which method comprises administering to the subject an antibody or an antigen-binding portion thereof that specifically binds to a Programmed Death-1 (PD-1) receptor and inhibits PD-1 activity. In some embodiments, the tumor is derived from a non-small cell lung cancer (NSCLC). In some embodiments, the tumor expresses Programmed Death Ligand 1. In some embodiments, the subject carries a wild-type STK11 gene.