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1. (WO2018223030) USE OF EZH2 INHIBITORS FOR TREATING CANCER

Pub. No.:    WO/2018/223030    International Application No.:    PCT/US2018/035655
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Sat Jun 02 01:59:59 CEST 2018
IPC: A61K 31/00
A61K 31/4162
A61K 31/497
Applicants: EPIZYME, INC.
Inventors: DAIGLE, Scott
COSMOPOULOS, Kat
Title: USE OF EZH2 INHIBITORS FOR TREATING CANCER
Abstract:
The disclosure provides methods of treating, identifying and/or selecting for treatment a subject having a cancer in which an immune checkpoint protein is upregulated. In certain embodiments, the methods for treating cancer in a subject in need thereof comprise administering to the subject: (a) a therapeutically effective amount of an EZH2 inhibitor and (b) a therapeutically effective amount of an immune checkpoint inhibitor. In certain embodiments of the methods of the disclosure, the EZH2 inhibitor is tazemetostat.