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1. (WO2018223023) METHODS FOR TREATMENT OF FIBROTIC DISEASES

Pub. No.:    WO/2018/223023    International Application No.:    PCT/US2018/035646
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Sat Jun 02 01:59:59 CEST 2018
IPC: A61K 31/4178
A61K 31/437
A61K 31/55
Applicants: BETA CAT PHARMACEUTICALS, INC.
Inventors: HAN, Ruolan
NORTHRUP, Jon
KASIBHATLA, Srinivas, Rao
HORRIGAN, Stephen
LARSON, Jeff
Title: METHODS FOR TREATMENT OF FIBROTIC DISEASES
Abstract:
Methods for treatment of fibrotic diseases using compounds of formula I wherein RA is hydrogen, R7 and R8 are independently selected from H and SO2NR3R4, one of R7 and R8 is hydrogen, and R1, R2, R3, and R4 are each independently selected from H, alkyl, heteroalkyl, cycloalkyl, arylcycloalkyl, aryl, heteroaryl, heterocycloalkyl, and each of NR1 R2 and NR3R4 can independently combine to form a heterocycloalkyl, and wherein said alkyl, heteroalkyl, cycloalkyl, arylcycloalkyl, aryl, heteroaryl, or heterocycloalkyl may be optionally substituted, or a pharmaceutically acceptable salt, ester, amide, stereoisomer, geometric isomer or prodrug thereof.