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1. (WO2018223014) DNA-GLYCAN CONJUGATES AND METHODS OF USE

Pub. No.:    WO/2018/223014    International Application No.:    PCT/US2018/035629
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Sat Jun 02 01:59:59 CEST 2018
IPC: C12Q 1/6837
C12N 15/10
G06F 19/22
Applicants: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATON, INC.
Inventors: WANG, Peng George
SONG, Jing
KONDENGADEN, Muhammed Shukkor
PARAMESWARAN, Aishwarya
Title: DNA-GLYCAN CONJUGATES AND METHODS OF USE
Abstract:
Provided herein are DNA-glycan conjugates that include a glycan and a covalently attached polynucleotide. The polynucleotide includes a plurality of modules. Each module includes a nucleotide string, and the plurality of modules includes a monomer module that corresponds to each carbohydrate monomer present in the DNA-glycan conjugate, and a linkage module that corresponds to each glycosidic linkage present between each carbohydrate monomer in the DNA-glycan conjugate. The nucleotide sequence of the plurality of modules corresponds to the glycan structure. Also provided herein are methods for making and using the DNA-glycan conjugates. Further provided is a computer-implemented method for translating data from a nucleotide sequence to a glycan structure, a system for converting data from a glycan structure to a nucleotide sequence, and a system for translating data from a nucleotide sequence to a glycan structure.