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1. (WO2018223008) PREDICTIVE FACTORS FOR PREDICTING LAPAROTOMY CLOSURE
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Pub. No.: WO/2018/223008 International Application No.: PCT/US2018/035620
Publication Date: 06.12.2018 International Filing Date: 01.06.2018
IPC:
G01N 33/68 (2006.01) ,A61K 38/18 (2006.01) ,A61B 17/03 (2006.01) ,A61B 17/08 (2006.01) ,A61B 19/00 (2006.01) ,A61B 17/00 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
18
Growth factors; Growth regulators
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
17
Surgical instruments, devices or methods, e.g. tourniquets
03
for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
17
Surgical instruments, devices or methods, e.g. tourniquets
03
for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith
08
Wound clamps
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
19
Instruments, implements or accessories for surgery or diagnosis not covered by any of the groups A61B1/-A61B18/149
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
17
Surgical instruments, devices or methods, e.g. tourniquets
Applicants:
THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. [US/US]; 6720-A Rockledge Drive Suite 100 Bethesda, Maryland 20817, US
Inventors:
GELBARD, Rondi; US
SCHOBEL-MCHUGH, Seth A.; US
ELSTER, Eric A.; US
GAUCHER, Beverly J.; US
Agent:
SMYTH, Robert; US
GROTE, Eric; US
LOWEN, Gregory T.; US
LEE, Janice H.; US
OHARA, Toyomi; US
Priority Data:
62/514,31502.06.2017US
Title (EN) PREDICTIVE FACTORS FOR PREDICTING LAPAROTOMY CLOSURE
(FR) FACTEURS DE PRÉDICTION POUR PRÉDIRE UNE FERMETURE DE LAPAROTOMIE
Abstract:
(EN) The present invention relates to methods of determining if a subject has an increased risk of developing unsuccessful fascial closure after laparotomy (UFC) prior to the onset of any detectable symptoms thereof. The methods comprise analyzing at least one sample from the subject to determine a value of the subject's risk profile and comparing the value of the subject's risk profile with the value of a normal risk profile. A change in the value of the subject's risk profile, over or under normal values is indicative that the subject has an increased risk of having or developing symptoms associated with UFC prior to the onset of any detectable symptoms thereof.
(FR) La présente invention concerne des procédés permettant de déterminer si un sujet présente ou non un risque accru de développer une fermeture faciale manquée après laparotomie (UFC) avant l'apparition de tout symptôme détectable de celle-ci. Les procédés consistent à analyser au moins un échantillon prélevé chez le sujet pour déterminer une valeur du profil de risque du sujet, et à comparer la valeur du profil de risque du sujet à la valeur d'un profil de risque normal. Une modification de la valeur du profil de risque du sujet au-dessus ou au-dessous de valeurs normales est indicateur du fait que le sujet présente un risque accru d'avoir ou de développer des symptômes associés à une UFC avant l'apparition de tout symptôme détectable de celle-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)