Search International and National Patent Collections

1. (WO2018223003) DETECTION OF PAR IN THE CSF OF PATIENTS WITH PARKINSON'S DISEASE

Pub. No.:    WO/2018/223003    International Application No.:    PCT/US2018/035614
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Sat Jun 02 01:59:59 CEST 2018
IPC: G01N 33/53
G01N 33/00
C07K 16/00
C12P 21/08
Applicants: THE JOHN HOPKINS UNIVERSITY
Inventors: DAWSON, Ted
DAWSON, Valina
KAM, Tae-In
ROSENTHAL, Liana
ANDRABI, Shaida
Title: DETECTION OF PAR IN THE CSF OF PATIENTS WITH PARKINSON'S DISEASE
Abstract:
Poly(ADP-ribose) (PAR) is a protein implicated in numerous neurodegenerative disease states including Parkinson's disease (PD). To date, no routine laboratory test has been developed to diagnosis, assess or monitor patients suffering from PD. Disclosed herein a novel method to assess the PAR concentration in the cerebral spinal fluid (CSF) of a patient and correlate that concentration to the medical condition of a patient with PD. Also disclosed is the use of PAR as a biomarker for PD.