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1. (WO2018222989) CERAMIDE NANOLIPOSOMES, COMPOSITIONS AND METHODS OF USING FOR IMMUNOTHERAPY

Pub. No.:    WO/2018/222989    International Application No.:    PCT/US2018/035594
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Sat Jun 02 01:59:59 CEST 2018
IPC: A61K 31/704
A61K 47/18
A61K 9/127
Applicants: THE PENN STATE RESEARCH FOUNDATION
Inventors: KESTER, Mark
STAVELEY-O'CARROLL, Kevin
LI, Guangfu
Title: CERAMIDE NANOLIPOSOMES, COMPOSITIONS AND METHODS OF USING FOR IMMUNOTHERAPY
Abstract:
Methods and compositions for treating cancer are provided. Compositions comprising ceramide nanoliposomes are administered to a subject in need of such treatment. The composition administration also enhances immunotherapy. Further administering compositions in combination with tumor antigen specific T-cells, and/or compositions in combination with tumor antigen expressing cells, and/or said compositions in combination with antagonists of PD-1 provides for enhanced results. Administration of the compositions provides for effective treatment of tumors including regression and eradication of established tumors.