Search International and National Patent Collections

1. (WO2018222987) TARGETED CONSTRUCTS

Pub. No.:    WO/2018/222987    International Application No.:    PCT/US2018/035592
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Sat Jun 02 01:59:59 CEST 2018
IPC: A61K 38/24
A61K 47/48
A61K 39/395
C07K 16/44
C07K 16/46
C07K 16/24
C12P 21/06
Applicants: TARVEDA THERAPEUTICS, INC.
Inventors: KADIYALA, Sudhakar
WOOSTER, Richard
BILODEAU, Mark T.
MOREAU, Benoît
WHITE, Brian H.
Title: TARGETED CONSTRUCTS
Abstract:
Protein-binding moieties, such as antibody mimetics that bind to proteins such as FcRn, albumin, or IgG, and targeted constructs comprising the protein-binding moieties have been designed which can provide improved temporospatial delivery of the active agent and/or improved biodistribution and half-lives. Methods of making the antibody mimetics, targeted constructs, and the pharmaceutical formulations thereof are provided. Methods of administering the pharmaceutical formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.