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1. (WO2018222983) PHENOTYPICALLY WILD-TYPE AND GENETICALLY ATTENUATED VIRUSES

Pub. No.:    WO/2018/222983    International Application No.:    PCT/US2018/035587
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Sat Jun 02 01:59:59 CEST 2018
IPC: A61K 39/21
C12N 7/00
Applicants: SHACKELTON, Laura
KERNER, Matthew
Inventors: SHACKELTON, Laura
KERNER, Matthew
Title: PHENOTYPICALLY WILD-TYPE AND GENETICALLY ATTENUATED VIRUSES
Abstract:
The disclosed compositions and methods provide an approach for the rational development of a live attenuated virus to be used as a vaccine, vaccine seed strain, therapy, and/or research tool. Methods are disclosed to generate a virus that is phenotypically wild-type but genetically attenuated. The virus would 'look' like the pathogenic virus and, upon vaccination, the initial viral infection would be largely, if not fully, indistinguishable from that initiated by its pathogenic counterpart, leading to the most relevant and robust immune response. However, because the genome is attenuated, the viruses generated by the initial round of infection would be phenotypically attenuated. This approach can be applied to any virus that, upon the introduction of select mutations, can be propagated with an organism or system that utilizes an alternative genetic code.