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1. (WO2018222962) PROMININ-1 PEPTIDE FOR TREATING LUNG INJURY

Pub. No.:    WO/2018/222962    International Application No.:    PCT/US2018/035549
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Sat Jun 02 01:59:59 CEST 2018
IPC: A61K 38/00
A61K 38/12
A61K 38/10
A61K 38/04
Applicants: CHILDREN'S MEDICAL CENTER CORPORATION
Inventors: ADINI, Avner
MATTHEWS, Benjamin
Title: PROMININ-1 PEPTIDE FOR TREATING LUNG INJURY
Abstract:
Described herein are compositions and methods for treating a lung disorder associated with dysregulated VEGF signaling. The PR1P peptide (DRVQRQTTTVVA, SEQ ID NO: 1) and variants thereof are able to enhance VEGF signaling in the lungs and reduce lung cell apoptosis (e.g., induced by toxicity or injury), thus treating the disorder.