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1. (WO2018222957) TREATMENT OF DEVELOPMENTAL DISORDERS WITH IMIDAZOLONE DERIVATIVES

Pub. No.:    WO/2018/222957    International Application No.:    PCT/US2018/035541
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Sat Jun 02 01:59:59 CEST 2018
IPC: A61K 31/4166
C07D 233/88
A61P 25/00
Applicants: OVID THERAPEUTICS INC.
Inventors: DURING, Matthew
Title: TREATMENT OF DEVELOPMENTAL DISORDERS WITH IMIDAZOLONE DERIVATIVES
Abstract:
Methods of treating developmental disorders such as Angelman syndrome, Fragile X syndrome, Fragile X-associated tremor/ataxia syndrome (FXTAS), Autistic Spectrum Disorder, Autism, Asperger's syndrome, pervasive developmental disorder, Childhood Disintegrative Disorder, Rett syndrome, Landau-Kleffner Syndrome, Prader-Willi Syndrome, Tardive Dyskinesia, a seizure disorder and/or Williams Syndrome with a compound of formula 1 or a pharmaceutically acceptable salt thereof, wherein X, R1, R2, m and n have the meanings set forth in the specification, are provided. The methods provide therapeutic compositions that may be used to improve one or more symptoms of the developmental disorder.