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1. (WO2018222929) ENHANCED TARGETED DELIVERY OF THERAPEUTIC AGENTS

Pub. No.:    WO/2018/222929    International Application No.:    PCT/US2018/035481
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Fri Jun 01 01:59:59 CEST 2018
IPC: A61K 47/64
A61K 47/50
A61K 47/66
Applicants: PRISM | PROTEOGENOMICS RESEARCH INSTITUTE FOR SYSTEMS MEDICINE
SCHNITZER, Jan, E.
OH, Philip, Sung-Whan
CHRASTINA, Adrian
LEVIN, Michael
Inventors: SCHNITZER, Jan, E.
OH, Philip, Sung-Whan
CHRASTINA, Adrian
LEVIN, Michael
Title: ENHANCED TARGETED DELIVERY OF THERAPEUTIC AGENTS
Abstract:
Methods and compositions for enhancing the therapeutic activity of agents at low doses as a result of improved targeted drug delivery, namely precision delivery, are described. The methods and compositions can be used to decrease the effective administered amounts of active therapeutic agents via precision delivery to targets capable of mediating active transport across the biological barrier formed by the vasculature that lines blood vessels. Antibodies (and other targeting agent species) to precisely deliver an active ingredient (i.e., a therapeutic agent) to cells expressing, for example, a target protein on their cell membranes, are also described, as are methods of treating disease.