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1. (WO2018222921) METHODS AND COMPOSITIONS FOR TREATING BILE ACID DIARRHEA, DIARRHEA ASSOCIATED WITH SMALL INTESTINE RESECTION OR GALLBLADDER REMOVAL, AND SHORT BOWEL SYNDROME

Pub. No.:    WO/2018/222921    International Application No.:    PCT/US2018/035471
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Fri Jun 01 01:59:59 CEST 2018
IPC: A61K 36/47
A61K 31/353
A61P 1/12
Applicants: NAPO PHARMACEUTICALS, INC.
Inventors: CONTE, Lisa, A.
CHATURVEDI, Pravin, R.
CONTE, Charles
Title: METHODS AND COMPOSITIONS FOR TREATING BILE ACID DIARRHEA, DIARRHEA ASSOCIATED WITH SMALL INTESTINE RESECTION OR GALLBLADDER REMOVAL, AND SHORT BOWEL SYNDROME
Abstract:
Presented herein are methods for treating bile acid diarrhea, short bowel syndrome (SBS), and cholecystectomy-associated diarrhea by administering to a patient in need thereof, an inhibitor of chloride-ion transport in an amount sufficient to treat diarrhea. In particular embodiments, infants, and juveniles with SBS are treated with an inhibitor of chloride-ion transport in an amount sufficient to treat diarrhea. Treatment of diarrhea includes the treatment of the diarrhea as well as the pain, abdominal discomfort and other symptoms associated with diarrhea. In one embodiment, the inhibitor of chloride-ion transport is crofelemer.