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1. (WO2018222919) METHODS AND COMPOSITIONS FOR TREATING CONGENITAL DIARRHEA DISORDER

Pub. No.:    WO/2018/222919    International Application No.:    PCT/US2018/035468
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Fri Jun 01 01:59:59 CEST 2018
IPC: A61P 1/00
A61P 1/04
A61P 1/12
Applicants: NAPO PHARMACEUTICALS, INC.
Inventors: CONTE, Lisa, A.
CHATURVEDI, Pravin, R.
Title: METHODS AND COMPOSITIONS FOR TREATING CONGENITAL DIARRHEA DISORDER
Abstract:
Presented herein are methods and compositions for treating congenital diarrheal disorders (CDD). Methods comprise administering to a patient in need thereof, an effective amount of a proanthocyanidin polymer composition from C. lechleri, preferably crofelemer. Administration of the proanthocyanidin polymer composition addresses the secretory diarrhea and symptoms associated therewith caused by the CDD and can improve nutritional status, electrolyte balance, hydration, growth and development of the patient.