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1. (WO2018222917) IRE1 SMALL MOLECULE INHIBITORS

Pub. No.:    WO/2018/222917    International Application No.:    PCT/US2018/035464
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Fri Jun 01 01:59:59 CEST 2018
IPC: C07D 403/04
A61K 31/517
A61K 31/4155
A61P 35/00
Applicants: QUENTIS THERAPEUTICS, INC.
Inventors: VACCA, Joseph P.
LI, Dansu
BETTIGOLE, Sarah
Title: IRE1 SMALL MOLECULE INHIBITORS
Abstract:
Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.