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1. (WO2018222907) PHAGE-MEDIATED MOLECULAR DETECTION METHODS AND RELATED ASPECTS
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Pub. No.: WO/2018/222907 International Application No.: PCT/US2018/035449
Publication Date: 06.12.2018 International Filing Date: 31.05.2018
IPC:
C12Q 1/04 (2006.01) ,C12Q 1/6888 (2018.01)
[IPC code unknown for C12Q 1/04][IPC code unknown for C12Q 1/6888]
Applicants:
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY [US/US]; Naval Medical Research Center 503 Robert Grant Avenue 1URO Silver Spring, MD 20910, US
Inventors:
BISWAS, Biswajit; US
MALAGON BAUTISTA, Francisco, Jesus; US
ESTRELLA, Luis, Angel; US
Agent:
TSO, Diane; US
Priority Data:
62/514,53402.06.2017US
Title (EN) PHAGE-MEDIATED MOLECULAR DETECTION METHODS AND RELATED ASPECTS
(FR) PROCÉDÉS DE DÉTECTION MOLÉCULAIRE À MÉDIATION PAR PHAGE ET ASPECTS ASSOCIÉS
Abstract:
(EN) Methods of detecting actively growing host organisms, including bacterial organisms, involving the detection of ribonucleic acid (RNA) products produced by unmodified infectious bioagenis that infect the host organisms are provided. Related methods of assessing drug susceptibility and resistance are further provided. In addition to these surrogate detection methods, related reaction mixtures, kits, systems, and microfluidic cards are also provided.
(FR) L'invention concerne des procédés de détection de croissance active d'organismes hôtes, y compris des organismes bactériens, impliquant la détection de produits d'acide ribonucléique (ARN) produits par des agents biologiques infectieux non modifiés qui infectent les organismes hôtes. L'invention concerne en outre des procédés associés d'évaluation de la sensibilité et de la résistance à un médicament. L'invention concerne également, en plus de ces procédés de détection de substitution, des mélanges réactionnels, des kits, des systèmes et des cartes microfluidiques associés.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)