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1. (WO2018222890) SYNTHESIS AND STRUCTURE OF HIGH POTENCY RNA THERAPEUTICS

Pub. No.:    WO/2018/222890    International Application No.:    PCT/US2018/035419
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Fri Jun 01 01:59:59 CEST 2018
IPC: C12N 15/82
Applicants: ARCTURUS THERAPEUTICS, INC.
Inventors: LIMPHONG, Pattraranee
PEREZ-GARCIA, Carlos G.
TACHIKAWA, Kiyoshi
CHIVUKULA, Padmanabh
CALE, Arisa
LEU, Angel I-Jou
DAVIS, Jared
Title: SYNTHESIS AND STRUCTURE OF HIGH POTENCY RNA THERAPEUTICS
Abstract:
This invention provides expressible polynucleotides, which can express a target protein or polypeptide. Synthetic mRNA constructs for producing a protein or polypeptide can contain one or more 5' UTRs, where a 5' UTR may be expressed by a gene of a plant. In some embodiments, a 5 UTR may be expressed by a gene of a member of Arabidopsis genus. The synthetic mRNA constructs can be used as pharmaceutical agents for expressing a target protein or polypeptide in vivo.